Creating a model to study interactions in the cervicovaginal environment
Official title: Biomimetic Models Core
Funded at University of Maryland Baltimore · NIH-11290893 · Data updated 2026-11-12
This study is creating a model that mimics the cervicovaginal area to learn how the natural bacteria there interact with infections like Chlamydia and gonorrhea, which could help find better ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $487,899 |
| NIH project number | 5U19AI158930-05 |
| Project ID | NIH-11290893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk for or currently experiencing infections caused by Chlamydia trachomatis or Neisseria gonorrhoeae.
✕Less likely to help
Patients who do not have cervicovaginal infections or are not at risk for these infections may not benefit from this research.
What this research studies
This research aims to develop a biomimetic model that simulates the cervicovaginal environment, including its microbiota, to better understand how these interactions influence the body's response to infections like Chlamydia trachomatis and Neisseria gonorrhoeae. By utilizing advanced techniques such as global transcriptomics and immune profiling, the study will explore the complex dynamics between the host, microbiome, and pathogens. This innovative approach will help researchers gain insights into the biological mechanisms at play during infections, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for infections affecting the cervicovaginal area.
How similar studies have gone: Other research has shown promise in using biomimetic models to study host-pathogen interactions, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Gleghorn, Jason Paul — University of Maryland Baltimore
- Study coordinator: Gleghorn, Jason Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.