Creating a knowledgebase for osteoarthritis research
Official title: The OAI Collaborative Osteoarthritis Research Enterprise (OAI CORE) Knowledgebase
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11015984 · Data updated 2026-11-12
This study is creating a helpful resource that brings together important information about knee osteoarthritis from nearly 4,800 people, making it easier for researchers to find and use this data to improve treatments and care for the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $533,151 |
| NIH project number | 1R24AR085006-01 |
| Project ID | NIH-11015984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with knee osteoarthritis or those at risk of developing it.
✕Less likely to help
Patients with osteoarthritis in joints other than the knee may not receive direct benefits from this research.
What this research studies
This research aims to develop a comprehensive knowledgebase that organizes and links extensive data related to the Osteoarthritis Initiative (OAI), which includes clinical data, medical images, and genetic information from nearly 4,800 individuals with or at risk for knee osteoarthritis. By centralizing this information, the project seeks to enhance the accessibility and utilization of OAI resources for researchers, ultimately accelerating discoveries in osteoarthritis treatment and management. The knowledgebase will employ modern technology and best practices to ensure high-quality data governance and support for the research community.
Why it matters
Potential benefit: If successful, this research could significantly improve the understanding and treatment of osteoarthritis, leading to better patient outcomes.
How similar studies have gone: Previous research utilizing centralized databases for osteoarthritis has shown promise, indicating that this approach could be effective.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Driban, Jeffrey B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Driban, Jeffrey B
Related research
Other NIH-funded projects on the same topics.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Identifying OA subtypes and early warning signs before joint damage
This grant asks researchers to find early, invisible clues of osteoarthritis subtypes so we can target treatments before joints are damaged.
-
Digital biomarkers to guide personalized rehab after ACL injury
Aims to use wearable sensors and phone videos to predict early osteoarthritis risk after ACL surgery so rehabilitation can be tailored to each patient.
-
Aberrant mechano-oxygen coupling linked to zinc-rich mineralization in osteoarthritis
Aims to understand how abnormal joint forces affect cartilage and bone, causing zinc-rich mineral deposits and harmful blood vessel growth in osteoarthritis.
-
Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets
Researchers are studying how Notch signaling affects TMJ osteoarthritis to identify new ways to protect and repair the jaw joint.
-
Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.