Coronary blood vessel resilience through mitochondrial antioxidant therapy
Official title: Coronary Vascular Resilience by Modulation of Mitochondrial ROS in Endothelium
Funded at Rhode Island Hospital · NIH-11378790 · Data updated 2026-11-12
Aims to see if boosting mitochondrial defenses in heart blood vessel cells helps them survive and grow during low-oxygen heart attacks, potentially aiding heart recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 1, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $648,799 |
| NIH project number | 5R01HL175045-02 |
| Project ID | NIH-11378790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at high risk for coronary artery disease or myocardial infarction who may be eligible for future human studies based on this preclinical research.
✕Less likely to help
This research is primarily preclinical in animal models; direct benefit to individual patients is not immediate.
What this research studies
This project focuses on heart artery endothelial cells and tests whether reducing mitochondrial reactive oxygen species (ROS) supports their energy production and survival in ischemic conditions. It builds on findings where targeted mito-antioxidants or mito-specific nanoparticles improved endothelial cell survival and function in animal heart injury models. The study will examine changes in mitochondrial energy pathways, respiratory complexes, and energy efficiency during low oxygen and low glucose states to support cardiac repair. If successful, this work could point to new ways to protect heart tissue after a myocardial infarction.
Why it matters
Potential benefit: If successful, patients could benefit from therapies that strengthen heart vessel cells during and after a heart attack, promoting better recovery.
How similar studies have gone: Previous preclinical work showed that mito-antioxidants improved endothelial cell survival and heart function after injury, supporting the approach's promise.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Abid, Ruhul — Rhode Island Hospital
- Study coordinator: Abid, Ruhul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.