Coordinating new HIV prevention methods worldwide
Official title: HIV Prevention Trials Network Leadership and Operations Center
Funded at Family Health International · NIH-11237571 · Data updated 2026-11-12
This program tests new HIV prevention tools—like long-acting medicines, combined products that also prevent pregnancy or STIs, and antibody treatments—for people at higher risk of HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Family Health International NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 1, 2006 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $21,000,000 |
| NIH project number | 5UM1AI068619-20 |
| Project ID | NIH-11237571 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are people at higher risk for HIV such as sexually active young adults, men who have sex with men, transgender women, female sex workers, people who inject drugs, and women in sub-Saharan Africa.
✕Less likely to help
People who are not at risk for HIV or those already living with untreated HIV seeking treatment rather than prevention are unlikely to benefit from these prevention-focused activities.
What this research studies
From your point of view, this program runs and organizes clinical work that tries to bring new ways to prevent HIV to the real world. It focuses on long-acting antiretroviral options for PrEP, multipurpose products that can prevent HIV and pregnancy or STIs, and antibody-based approaches, and it works with many communities at risk. The network designs trials, coordinates sites, manages safety and data, and partners with other research groups to try combined prevention approaches. If you are in a community the network serves, you might be able to join a study or contribute samples to help develop better prevention options.
Why it matters
Potential benefit: If successful, this work could expand practical prevention choices—like long-acting PrEP, products that prevent HIV plus pregnancy or STIs, or antibody-based protection—reducing new HIV infections.
How similar studies have gone: Previous trials, including HPTN and other networks, have shown strong results for long-acting PrEP (e.g., cabotegravir) and ongoing work on multipurpose products and broadly neutralizing antibodies shows promise but remains more experimental.
Where this research is happening
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Family Health International
Durham, United States Active
Researchers
- Principal investigator: Landovitz, Raphael J — Family Health International
- Study coordinator: Landovitz, Raphael J
Related research
Other NIH-funded projects on the same topics.
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Making HIV prevention and care easier for Ugandan youth
A Ugandan study is testing ways to help adolescents and young adults (15–24) prevent HIV and stay healthy, using long-acting PrEP and youth-friendly services.
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Innovative HIV Prevention and Care Interventions for Adolescents and Young Adults in Uganda
A Ugandan research team is testing practical, youth-focused strategies to help 15-24 year-olds using HIV prevention or treatment services stay healthy and engaged in care.
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Adolescent girls in Uganda: a long-term look at how money empowerment and family support affect HIV prevention, care, and mental health
A long-term study in rural Uganda will test whether an intervention that combines economic empowerment and family strengthening can help HIV-negative and HIV-affected adolescent girls move safely into young adulthood.
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Long-term HIV prevention and mental health support for adolescent girls and young women in Uganda
A long-term program in rural Uganda tests if combining economic support and family strengthening helps teenage girls stay HIV-free and improve mental health as they grow into young adults.
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Harnessing male peer networks to boost HIV testing and PrEP use
A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.
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Harnessing men's peer networks to boost HIV self-testing and PrEP use
A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.