Comparing how heart inotropes are used after surgery
Official title: COmparing iNoTRope prACtice variaTION in Cardiac Surgery (CONTRACTION-CS)
Funded at University of Michigan at Ann Arbor · NIH-11229615 · Data updated 2026-11-12
Researchers will look at how doctors decide to use heart-strengthening medicines after heart surgery and why some patients fare better or worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $680,300 |
| NIH project number | 5R01HL167790-03 |
| Project ID | NIH-11229615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who are undergoing or have recently undergone cardiac surgery and may need inotrope support.
✕Less likely to help
Patients not receiving inotropes or not undergoing cardiac surgery may not benefit from these findings.
What this research studies
After cardiac surgery, certain medicines called inotropes are used to boost heart pumping, but their risks and benefits vary by patient. This project aims to understand when these medicines help and when they may cause harm across a broad group of adults in real hospital settings. The study will analyze patient data from multiple centers to identify patterns of inotrope use and associated outcomes, with the goal of guiding more personalized treatment decisions. By comparing different practice patterns, the researchers hope to reduce complications and improve survival after surgery.
Why it matters
Potential benefit: If successful, the work could lead to more personalized, safer use of inotropes after cardiac surgery and potentially fewer complications.
How similar studies have gone: Prior research has shown variation in inotrope use and related outcomes; this study aims to generalize findings to a broad contemporary population.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mathis, Michael Robert — University of Michigan at Ann Arbor
- Study coordinator: Mathis, Michael Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.