How surgery affects brain function in older adults with dementia.
Immunovascular interactions in postoperative delirium superimposed on dementia (DSD).
This study is looking at how surgery affects the brains of older adults with dementia, especially how inflammation from the surgery might lead to confusion or delirium, and it aims to find ways to help these patients feel better after their operations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10524797 on NIH RePORTER |
What this research studies
This research investigates the impact of surgical trauma on brain function in older adults, particularly those with pre-existing dementia. It focuses on understanding how systemic inflammation from surgery can lead to delirium, a serious condition that can worsen outcomes for these patients. By using a mouse model that mimics delirium-like behavior after orthopedic surgery, the study aims to uncover the mechanisms behind blood-brain barrier dysfunction and neuroinflammation. The ultimate goal is to identify ways to mitigate these effects and improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with dementia who are scheduled for surgical procedures.
Not a fit: Patients without dementia or those who are not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for preventing delirium in older adults undergoing surgery, potentially improving their recovery and overall outcomes.
How similar studies have performed: Previous research has indicated that systemic inflammation and blood-brain barrier dysfunction are critical factors in neurodegenerative conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Terrando, Niccolo — Duke University
- Study coordinator: Terrando, Niccolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.