Choosing Immune Suppression in Kidney Transplantation for Better Long-Term Graft Health

Who could benefit from this research

What this research studies

This project uses large health data from kidney transplant patients to create a richer, more actionable picture of how different immune-suppressing medicines affect long-term graft health and safety. It builds on past work and adds more detailed clinical information and lab results to support better, shared decision-making between patients and clinicians. Researchers will link national transplant data with medical records and pharmacy information to study long-term outcomes like infections, cancer, diabetes, rejection, and survival. A patient-facing web tool will help providers and patients choose regimens that balance effectiveness with risks. The goal is to improve personalized care and outcomes for people living with kidney transplants.

Why it matters

Where this research is happening

• Rutgers Biomedical and Health Sciences
  Newark, United States Active

Researchers

• Principal investigator: Dharnidharka, Vikas R. — Rutgers Biomedical and Health Sciences
• Study coordinator: Dharnidharka, Vikas R.

Related research

Other NIH-funded projects on the same topics.

• Understanding how antibodies are produced after kidney transplants

  This study is looking at how certain immune cells in the body create antibodies that can cause kidney transplants to be rejected, especially after the kidneys have been stored in cold conditions, and it aims to find ways to help improve transplant success for patients.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11012825

• Identifying biomarkers to improve kidney transplant outcomes in children and young adults

  This study is looking for ways to help kids and young adults who have had kidney transplants live longer and healthier by finding special signs that can predict how well their transplant will work.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10911231

• Pilates exercises to improve balance, fatigue, and quality of life after kidney transplant

  This study tests whether adding Pilates to standard physical therapy helps people aged 20–50 after a kidney transplant feel steadier, less fatigued, and have a better quality of life.

  Recruiting Cairo University · Damanhur, Beheira and 1 other locations · NCT07626086

• Transversalis fascia plane block to reduce pain after kidney transplant

  See if a transversalis fascia plane block can reduce pain and opioid use after kidney transplant for adults aged 18–65 with ASA III.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT07542028

• Preoperative sensory modulation room to reduce pain, anxiety, and improve sleep for living kidney donors and recipients

  The team will try a short preoperative session in a sensory modulation room to see if it lowers postoperative pain, reduces anxiety, and improves sleep for adult living kidney donors and transplant recipients.

  Recruiting Sakarya University · Sakarya · NCT07533669

• Emotion-focused therapy to improve emotion regulation and well-being after kidney transplant

  This project will try an emotion-focused therapy to see if it helps adults who have had a kidney transplant manage their emotions and feel better.

  Recruiting Akdeniz University · Antalya · NCT07294183

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.