Identifying biomarkers to improve kidney transplant outcomes in children and young adults
Clinical and Molecular Biomarkers of Endpoints in Pediatric Renal Transplantation
This study is looking for ways to help kids and young adults who have had kidney transplants live longer and healthier by finding special signs that can predict how well their transplant will work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10911231 on NIH RePORTER |
What this research studies
This research focuses on improving the survival rates of kidney transplants in pediatric and young adult patients by identifying clinical and molecular biomarkers that can predict transplant outcomes. The study aims to develop better diagnostic tools that are specifically tailored for younger patients, addressing the unique challenges they face. By integrating clinical features with traditional histology and molecular biomarkers, the research seeks to enhance early detection of kidney transplant injuries, potentially leading to more effective interventions. The ultimate goal is to increase the longevity and quality of life for young individuals with end-stage renal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric and young adult patients undergoing kidney transplantation or those who have received a transplant.
Not a fit: Patients who are not undergoing kidney transplantation or are outside the pediatric and young adult age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the long-term success of kidney transplants in children and young adults, enhancing their life expectancy and quality of life.
How similar studies have performed: Previous studies in adult populations have shown success in using molecular biomarkers for kidney transplant outcomes, but this approach is novel for pediatric patients.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Seifert, Michael Edward — University of Alabama at Birmingham
- Study coordinator: Seifert, Michael Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.