Understanding how antibodies are produced after kidney transplants
Official title: Mechanisms of alloantibody production following renal transplantation
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11012825 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body create antibodies that can cause kidney transplants to be rejected, especially after the kidneys have been stored in cold conditions, and it aims to find ways to help improve transplant success for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | February 22, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $578,905 |
| NIH project number | 5R01AI160740-05 |
| Project ID | NIH-11012825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received a kidney transplant and are at risk of antibody-mediated rejection.
✕Less likely to help
Patients who have not undergone kidney transplantation or those with other types of organ transplants may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the production of donor-specific antibodies that can lead to rejection of transplanted kidneys. It focuses on the role of specific B cell types in generating these antibodies, particularly after the kidneys have been subjected to cold storage before transplantation. By using a mouse model, the study aims to uncover how inflammation after transplantation influences antibody generation, which could help improve transplant outcomes for patients. The ultimate goal is to find ways to reduce harmful immune responses in kidney transplant recipients.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for antibody-mediated rejection in kidney transplant patients.
How similar studies have gone: Previous research has shown that understanding immune responses in transplantation can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Valujskikh, Anna — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Valujskikh, Anna
Related research
Other NIH-funded projects on the same topics.
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Choosing Immune Suppression in Kidney Transplantation for Better Long-Term Graft Health
A patient-friendly look at a study aimed at optimizing immune-suppressing medicines after kidney transplant to improve graft survival and reduce complications.
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Identifying biomarkers to improve kidney transplant outcomes in children and young adults
This study is looking for ways to help kids and young adults who have had kidney transplants live longer and healthier by finding special signs that can predict how well their transplant will work.
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Pilates exercises to improve balance, fatigue, and quality of life after kidney transplant
This study tests whether adding Pilates to standard physical therapy helps people aged 20–50 after a kidney transplant feel steadier, less fatigued, and have a better quality of life.
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See if a transversalis fascia plane block can reduce pain and opioid use after kidney transplant for adults aged 18–65 with ASA III.
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The team will try a short preoperative session in a sensory modulation room to see if it lowers postoperative pain, reduces anxiety, and improves sleep for adult living kidney donors and transplant recipients.
-
Emotion-focused therapy to improve emotion regulation and well-being after kidney transplant
This project will try an emotion-focused therapy to see if it helps adults who have had a kidney transplant manage their emotions and feel better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.