Understanding how antibodies are produced after kidney transplants
Mechanisms of alloantibody production following renal transplantation
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11012825
This study is looking at how certain immune cells in the body create antibodies that can cause kidney transplants to be rejected, especially after the kidneys have been stored in cold conditions, and it aims to find ways to help improve transplant success for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11012825 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the production of donor-specific antibodies that can lead to rejection of transplanted kidneys. It focuses on the role of specific B cell types in generating these antibodies, particularly after the kidneys have been subjected to cold storage before transplantation. By using a mouse model, the study aims to uncover how inflammation after transplantation influences antibody generation, which could help improve transplant outcomes for patients. The ultimate goal is to find ways to reduce harmful immune responses in kidney transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are at risk of antibody-mediated rejection.
Not a fit: Patients who have not undergone kidney transplantation or those with other types of organ transplants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for antibody-mediated rejection in kidney transplant patients.
How similar studies have performed: Previous research has shown that understanding immune responses in transplantation can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VALUJSKIKH, ANNA — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: VALUJSKIKH, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.