Chlamydia pneumoniae infection and Alzheimer's disease progression
Official title: The role of Chlamydia pneumoniae infection in Alzheimer's Disease
Funded at Cedars-Sinai Medical Center · NIH-11538116 · Data updated 2026-11-12
This project looks at whether a common lung infection, Chlamydia pneumoniae, might influence Alzheimer's disease in people and what that could mean for treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 30, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $427,726 |
| NIH project number | 3R01AG075998-05S1 |
| Project ID | NIH-11538116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with late-onset Alzheimer's disease or at risk for AD who have clinical data or samples available for study.
✕Less likely to help
Results may not directly benefit individuals who do not have or are not at risk for Alzheimer's disease.
What this research studies
Researchers at Cedars-Sinai will explore if Chlamydia pneumoniae infection can impact the development or progression of Alzheimer’s disease by examining biological links in patient samples and existing data. The study will use human-derived materials and clinical information to understand inflammatory pathways that might connect infection to brain changes seen in AD. By identifying how Cp infection could accelerate AD pathology, findings could guide future therapies or prevention strategies for patients at risk. The project spans several years and aims to connect infectious biology with neurodegenerative processes in people living with AD or at risk for it.
Why it matters
Potential benefit: If successful, the work could lead to new approaches to prevent or slow Alzheimer's progression by targeting infection-related pathways.
How similar studies have gone: Prior research has linked Cp infection to inflammation and disease, but definitive mechanisms in AD require further confirmation and translation to therapies.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Crother, Timothy Robert — Cedars-Sinai Medical Center
- Study coordinator: Crother, Timothy Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.