Chemoprevention of head and neck cancer with a natural compound mix
Official title: Chemoprevention of head and neck cancer using combination of natural compounds
Funded at Marshall University · NIH-11441577 · Data updated 2026-11-12
A study tests a natural combo of EGCG and resveratrol to help prevent head and neck cancer from developing.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | August 1, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $295,000 |
| NIH project number | 1R03DE036365-01 |
| Project ID | NIH-11441577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals at high risk for head and neck squamous cell carcinoma or those with premalignant lesions.
✕Less likely to help
Patients without premalignant lesions or at low risk may not benefit from this preventive approach.
What this research studies
This project explores whether two diet-derived compounds, EGCG and resveratrol, can work together to prevent head and neck cancer in people at risk. Researchers will look at how this combination affects cellular pathways related to detoxification and protection against oxidative stress, which are linked to cancer development. The work will be conducted using preclinical models and available data to support future translation to human studies. If successful, it could lead to a simple, natural approach to reduce cancer risk before invasive disease appears.
Why it matters
Potential benefit: If successful, the approach could reduce the risk of head and neck cancer by helping the body detoxify harmful substances and protect cells from oxidative damage.
How similar studies have gone: Earlier work suggests that EGCG and resveratrol can trigger synergistic cell-killing effects in cancer models, supporting further investigation.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Amin, A.r.m. Ruhul — Marshall University
- Study coordinator: Amin, A.r.m. Ruhul
Related research
Other NIH-funded projects on the same topics.
-
Combined Imaging and RNA Markers to Predict Head and Neck Cancer Recurrence
A research project aims to use imaging and RNA data to better predict if head and neck cancer will come back, helping doctors tailor treatments for patients.
-
Biomarker to guide treatment in head and neck cancer
A biomarker test using tumor samples is being developed to predict recurrence risk in oral cancers and help tailor treatment.
-
Intensive dental care during cancer follow-up to protect teeth after head and neck radiation
A program delivered in oncology clinics to provide fluoride varnish and dental follow-up aims to reduce tooth decay and improve oral health and quality of life for head and neck cancer patients after radiation therapy.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A computer program helps plan radiation therapy for cervical and head-and-neck cancer patients to make treatments faster and more accurate.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A United Kingdom study is testing AI software that helps plan radiotherapy for cervical and head-and-neck cancer patients to save time and reduce the workload for clinicians in low-resource settings.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A UK research team is testing an AI-based software to automatically outline cancer areas and plan radiation beams to speed up treatment for cervical and head-and-neck cancers in LMICs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.