Cellular and Molecular Studies of Bone Marrow Transplant and GVHD
Official title: Cellular and Molecular Studies of Bone Marrow Transplant
Funded at Icahn School of Medicine at Mount Sinai · NIH-11400426 · Data updated 2026-11-12
Researchers are studying why graft-versus-host disease happens after bone marrow transplant and how to predict and prevent it for people who need this cancer treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 10, 1997 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,520,987 |
| NIH project number | 5P01CA039542-37 |
| Project ID | NIH-11400426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing allogeneic hematopoietic cell transplantation who are at risk for or developing GVHD, particularly GI GVHD.
✕Less likely to help
Patients not undergoing bone marrow transplant or those not at risk for GVHD may not directly benefit.
What this research studies
This project aims to uncover the basic biology of GVHD, especially in the gut, and to develop laboratory methods that could forecast long‑term outcomes. It also plans to test new therapeutic approaches in early clinical trials to reduce GVHD and improve transplant success. The work includes examining intestinal stem cells, mitochondrial enzymes, and stress pathways to understand how GVHD damages the GI tract and how regeneration can be supported. Collaboration between projects and cores will translate lab findings into potential treatments for patients undergoing allogeneic hematopoietic cell transplantation.
Why it matters
Potential benefit: If successful, the research could lead to better prediction and prevention of GVHD, increasing the safety and effectiveness of bone marrow transplants.
How similar studies have gone: Prior studies suggest targeting stem cell biology and regeneration pathways can influence GVHD outcomes, but this program seeks to translate those findings into clinically testable strategies.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Ferrara, James L. M. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ferrara, James L. M.
Related research
Other NIH-funded projects on the same topics.
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Targeting early oral GVHD to improve mouth health after stem cell transplant
A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.
-
Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
-
Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Diabetes and Donor Tissue in Corneal Transplants
This grant studies whether corneas from donors with diabetes affect the success of Descemet membrane endothelial keratoplasty (DMEK) and what factors predict better or worse outcomes.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Medicare Advantage and Transplant Access for Rural and Vulnerable Communities
Aimed at understanding how Medicare Advantage affects early steps to kidney transplant for adults in rural or socioeconomically challenged groups.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.