Cell Competition in Myeloproliferative Neoplasms
Funded at State University New York Stony Brook · NIH-11380052 · Data updated 2026-11-12
This NIH grant explores how healthy and mutant blood stem cells interact in certain blood cancers to understand why some patients progress and how future therapies might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $362,298 |
| NIH project number | 5R01CA266294-05 |
| Project ID | NIH-11380052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with myeloproliferative neoplasms, including those with JAK2V617F mutations, or individuals with clonal hematopoiesis who might benefit from future therapies.
✕Less likely to help
Individuals without MPNs or related clonal hematopoiesis are unlikely to benefit from this study.
What this research studies
This project studies how white blood cell precursors with and without cancer-causing mutations compete inside the bone marrow. Using lab dish tests and animal transplant models, researchers examine how the microenvironment influences mutant cell growth and how wild-type cells may limit that growth. The goal is to uncover pathways that could be targeted to prevent progression to leukemia and improve outcomes after stem cell transplantation. Findings could inform new strategies to manage myeloproliferative neoplasms and related clonal hematopoiesis in patients.
Why it matters
Potential benefit: Could lead to new treatment approaches that slow or prevent leukemia in people with myeloproliferative neoplasms.
How similar studies have gone: Previous work showed that supportive wild-type cells can restrain mutant cell expansion in a controlled setting, supporting the potential for translational advances.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Zhan, Huichun — State University New York Stony Brook
- Study coordinator: Zhan, Huichun
Related research
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A large research collaboration across multiple centers aims to improve survival for patients with myelofibrosis and related myeloproliferative neoplasms through coordinated laboratory, translational, and clinical work.
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Understanding how different CALR mutations drive certain blood cancers
This grant explores how two CALR mutation types cause myeloproliferative neoplasms and could lead to better treatments for people with these blood cancers.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.