Understanding how inflammation and biology drive blood cancer evolution
Official title: Intrinsic and Extrinsic FactorsDriving Clonal Evolution and Disease Progression in Myeloproliferative Neoplasms
Funded at Washington University · NIH-11348769 · Data updated 2026-11-12
A large, multi-project program at Washington University is exploring how inflammatory signals and cell-intrinsic factors work together to drive progression of myeloproliferative neoplasms in people.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,355,825 |
| NIH project number | 1P01HL185367-01 |
| Project ID | NIH-11348769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with myeloproliferative neoplasms, including those with JAK2 mutations, who can contribute biospecimens or participate in related clinical studies.
✕Less likely to help
Patients without MPN-related biology or those not eligible for any associated clinical or biospecimen studies may not benefit.
What this research studies
This Program Project Grant brings together four research projects and three cores to study why certain blood cancers called myeloproliferative neoplasms progress and spread. Researchers will look at how inflammatory cytokines interact with cellular pathways to promote clonal expansion and disease progression, using advanced molecular and bioinformatics methods. The effort emphasizes collaboration among experienced scientists and leverages shared biospecimens and pathology resources to understand disease mechanisms. The work aims to generate integrated insights that could inform new approaches to diagnosis and treatment for patients with MPNs.
Why it matters
Potential benefit: If successful, the program could identify new targets and strategies to slow or halt MPN progression and improve patient outcomes.
How similar studies have gone: The project builds on an established track record of collaboration and prior publications among the investigators, indicating a solid foundation for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Oh, Stephen — Washington University
- Study coordinator: Oh, Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.