CC16 in childhood and resilience to early airflow limitation in adult life
Funded at University of Arizona · NIH-11511727 · Data updated 2026-11-12
A long-term study looks at whether a lung-protective protein called CC16 in children helps prevent early breathing problems that can lead to COPD in adulthood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 25, 2017 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $56,165 |
| NIH project number | 3R01AI135108-07S5 |
| Project ID | NIH-11511727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include children and adults with a history or risk of reduced lung growth and early airway changes
✕Less likely to help
Individuals without a history of early lung growth issues or COPD risk may not directly benefit
What this research studies
This project follows people from childhood into adulthood to see how CC16 levels relate to lung development and the risk of early airway problems. It focuses on identifying if higher CC16 during childhood can shield against pre-COPD changes and later COPD. The approach uses existing data and biomarkers to understand how early life factors influence respiratory health years later. It aims to uncover biological clues that could guide future prevention and treatment strategies for those at risk.
Why it matters
Potential benefit: If successful, the findings could inform early-life strategies to reduce COPD risk by supporting protective airway biology.
How similar studies have gone: Prior work suggests CC16 has anti-inflammatory effects and may influence airway health, but direct links to long-term COPD resilience require confirmation
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Guerra, Stefano — University of Arizona
- Study coordinator: Guerra, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.