CC16 in childhood and resilience to early airflow limitation in adult life
Funded at University of Arizona · NIH-11511723 · Data updated 2026-11-12
A study to understand how a protein called CC16 may protect children with early airway issues from developing breathing problems later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 25, 2017 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $10,800 |
| NIH project number | 3R01AI135108-07S1 |
| Project ID | NIH-11511723 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with early signs of impaired lung growth or airway issues who could be followed into adulthood.
✕Less likely to help
Children or adults without early airway risk factors or lung function deficits may not benefit from this research.
What this research studies
This project follows people from childhood into adulthood to see if higher levels of CC16 in the blood protect against early airway problems and pre-COPD. Researchers will examine how CC16 might reduce airway inflammation and leukocyte movement into the lungs, potentially preventing later COPD. The study builds on prior work and uses measurements of CC16 and lung function to identify who remains healthier over time. By uncovering protective factors in early life, this research aims to inform strategies for preventing chronic lung disease.
Why it matters
Potential benefit: If successful, findings could lead to new ways to prevent COPD by boosting CC16-related protection early in life.
How similar studies have gone: Prior research suggests CC16 may have anti-inflammatory effects that protect airways, but long-term protective impact is not fully established.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Guerra, Stefano — University of Arizona
- Study coordinator: Guerra, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.