CC16 and resilience to early lung problems into adulthood
Official title: CC16 in childhood and resilience to early airflow limitation in adult life
Funded at University of Arizona · NIH-11511725 · Data updated 2026-11-12
A study from the University of Arizona looks at whether a small lung protein called CC16 helps protect children with early signs of breathing problems from developing COPD-related issues later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 25, 2017 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $8,938 |
| NIH project number | 3R01AI135108-07S3 |
| Project ID | NIH-11511725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with early signs of impaired lung function and adults who may be at risk due to their childhood lung trajectory.
✕Less likely to help
If your lung development followed a typical trajectory with normal CC16 levels, you may not experience a direct benefit.
What this research studies
This project follows people from early childhood into adulthood to see if CC16, a molecule in the lungs, helps prevent long-term airway problems. It explores how having higher or lower CC16 levels might influence lung growth and the risk of pre-COPD in those who started life with impaired lung function. Researchers believe CC16’s anti-inflammatory effects could reduce lung inflammation and airway obstruction, potentially slowing or altering the trajectory toward COPD. The study builds on prior findings and aims to identify people who might benefit from CC16-related interventions or monitoring long before COPD manifests.
Why it matters
Potential benefit: Understanding CC16's role could lead to new ways to prevent or delay COPD in people who started life with smaller lungs.
How similar studies have gone: Previous work suggests CC16 may protect against lung inflammation, but confirmation in relation to early-life trajectories and COPD risk is ongoing.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Guerra, Stefano — University of Arizona
- Study coordinator: Guerra, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.