CC16 and resilience to early airflow limitation from childhood to adulthood
Official title: CC16 in childhood and resilience to early airflow limitation in adult life
Funded at University of Arizona · NIH-11511726 · Data updated 2026-11-12
A study looking at how a protein in the lungs (CC16) might protect children with early lung issues from developing airway problems later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 25, 2017 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $4,620 |
| NIH project number | 3R01AI135108-07S4 |
| Project ID | NIH-11511726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with a history of early-life lung function issues or at-risk children and adults who could be followed for long-term lung health.
✕Less likely to help
Study does not directly test a new treatment in participants; it analyzes biomarkers and trajectories.
What this research studies
This research follows people from childhood into adulthood to see if higher levels of CC16 in the blood help prevent early lung problems from turning into reduced lung function later on. It will use existing data and biological samples to explore how CC16 interacts with inflammation and lung development over time. The goal is to understand whether this protein could be a marker or even a target to support better lung health for those at risk of pre-COPD and COPD. Participants' past and current health information will guide analyses to identify who might benefit from early interventions.
Why it matters
Potential benefit: If successful, findings could inform strategies to reduce COPD risk by focusing on CC16-related pathways in at-risk children and adults.
How similar studies have gone: Prior work suggests CC16 is linked to airway inflammation and protection, supporting potential relevance in humans.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Guerra, Stefano — University of Arizona
- Study coordinator: Guerra, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.