Bronchiolitis Obliterans: turning biology insights into potential therapy

Who could benefit from this research

What this research studies

Bronchiolitis Obliterans Syndrome (BOS) is a severe, often fatal lung complication after allogeneic stem cell transplantation. This grant uses organoid models and immunogenomics to identify the cellular and antigen targets driving BOS and tests a promising drug, KD025, in a clinical trial. The team will combine lab models with patient-oriented research to understand how dysregulated immunity causes fibrosis and to see if KD025 can reduce this scarring. If successful, the work could reveal new pathways and a viable treatment approach for BOS patients.

Why it matters

Where this research is happening

• Dana-Farber Cancer Inst
  Boston, United States Active

Researchers

• Principal investigator: Cutler, Corey S — Dana-Farber Cancer Inst
• Study coordinator: Cutler, Corey S

Related research

Other NIH-funded projects on the same topics.

• Airway basal cell stress and environmentally caused bronchiolitis obliterans

  Researchers are studying how certain inhaled chemicals may damage the airway’s foundational cells and lead to a serious lung disease called bronchiolitis obliterans.

  NIH research University of Rochester · Rochester, United States · NIH-11418446

• Interrupting harmful lung cell interactions to reduce fluid leakage in critically ill children with bronchiolitis

  AYA pediatric patients with bronchiolitis who are severely ill may benefit from a study that targets lung cell signals to lessen fluid leak and improve breathing.

  NIH research Yale University · New Haven, United States · NIH-11401847

• Airway stem cell problems in transplant-related obliterative bronchiolitis

  This work looks at how airway stem cells change after lung transplant to help people who develop obliterative bronchiolitis.

  NIH research University of Iowa · Iowa City, United States · NIH-11316996

• Lymphatic changes after lung transplant and risk of bronchiolitis obliterans

  Researchers are looking at how damage or repair of the lung's lymphatic vessels after transplant affects the chance of developing bronchiolitis obliterans in people who receive lung transplants.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11251739

• How respiratory viruses affect long-term lung damage after donor stem cell transplant

  Following people who had donor stem cell transplants to see how common respiratory viruses relate to long-term lung damage called bronchiolitis obliterans syndrome.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11237165

• Bronchiolitis obliterans after stem-cell transplant: causes and new treatments

  This project tries a new drug called KD025 (a ROCK2 blocker) to help people who develop bronchiolitis obliterans after an allogeneic stem-cell transplant.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11174489

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.