BioGRID: A public hub for biological interactions and disease network data
Official title: BioGRID: An open resource for biological interaction data and disease network analysis
Funded at Hospital for Sick Chldrn (Toronto) · NIH-11450414 · Data updated 2026-11-12
A publicly available resource that collects and organizes known biological interactions to help researchers study how diseases like Alzheimer’s and autism are connected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Sick Chldrn (Toronto) NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | May 15, 2007 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $968,116 |
| NIH project number | 2R01OD010929-20 |
| Project ID | NIH-11450414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians studying Alzheimer’s disease, autism, and related conditions who rely on integrated interaction networks.
✕Less likely to help
Direct patient benefit may be limited for individuals not involved in data-driven research or not affected by the diseases targeted.
What this research studies
This grant supports expanding BioGRID, an open repository of genetic, protein, and chemical interactions, so scientists can use AI tools to map complex networks related to diseases such as Alzheimer’s and autism. The project combines automated AI-assisted data extraction with expert review to curate millions of interactions from research papers. By growing curated datasets and adding CRISPR screen data, it aims to make it easier for patients and clinicians to understand disease pathways and identify potential therapeutic targets. The work centers on improving data accessibility and AI-driven discovery for human health.
Why it matters
Potential benefit: If successful, patients may benefit from faster translation of research findings into new therapies and a clearer understanding of disease mechanisms.
How similar studies have gone: Similar open biomedical data resources have accelerated discoveries when combined with AI, though expansion of curated interactions remains an evolving field.
Where this research is happening
-
Hospital for Sick Chldrn (Toronto)
Toronto, Canada Active
Researchers
- Principal investigator: Tyers, Mike — Hospital for Sick Chldrn (Toronto)
- Study coordinator: Tyers, Mike
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.