Understanding how bone and soft tissue cancers develop in children
Official title: Discovering the Timing and Origins of Bone and Soft Tissue Cancers
Funded at Hospital for Sick Chldrn (Toronto) · NIH-10891705 · Data updated 2026-11-12
This study is looking into how bone and soft tissue cancers start in children and when they develop, with the goal of finding ways to catch these cancers earlier and improve treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Sick Chldrn (Toronto) NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $88,660 |
| NIH project number | 5R03CA283675-02 |
| Project ID | NIH-10891705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with bone or soft tissue sarcomas, as well as those at risk for these conditions.
✕Less likely to help
Patients with cancers unrelated to bone or soft tissue sarcomas may not benefit from this research.
What this research studies
This research investigates the origins and timing of bone and soft tissue cancers, particularly in children. It aims to identify the early mutations and cells that lead to these cancers, which often go undiagnosed for years. By analyzing over 6,000 samples, the researchers will map out the development of these tumors from their inception to potential relapse. This work could help improve early detection and treatment strategies for childhood sarcomas.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for childhood bone and soft tissue cancers.
How similar studies have gone: Previous research has shown promise in understanding the genetic origins of childhood cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Hospital for Sick Chldrn (Toronto)
Toronto, Canada Active
Researchers
- Principal investigator: Shlien, Adam — Hospital for Sick Chldrn (Toronto)
- Study coordinator: Shlien, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.