Basophil-fibroblast signals driving inflammation in atopic dermatitis

Who could benefit from this research

What this research studies

This project investigates how basophils release signals like IL-4/IL-13 and OSM that may activate skin fibroblasts to produce inflammatory chemicals. By using genetic approaches to reduce basophil activity and their signals in AD-like inflammation, the team will see if overall skin inflammation decreases and fibroblast inflammatory features lessen. The study also examines how activated fibroblasts recruit immune cells and worsen skin disease, linking cellular conversations to symptoms. Findings from mouse models will be compared to human tissue data to gauge relevance to people with atopic dermatitis.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Ji, Andrew — Icahn School of Medicine at Mount Sinai
• Study coordinator: Ji, Andrew

Related research

Other NIH-funded projects on the same topics.

• Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin

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• SEAL Study: Preventing peanut allergy by protecting baby skin

  This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11532533

• SEAL Study: Prevent allergy by protecting the baby’s skin

  A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11516452

• Understanding how skin fungi affect atopic dermatitis in adults

  A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11435642

• Preventing eczema-related allergies by strengthening infants' skin barrier

  This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11418544

• Personalized predictions for how atopic dermatitis may progress in kids and teens

  A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11418025

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.