Aspirin-Exacerbated Respiratory Disease: How it develops and how we might treat it
Official title: Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease
Funded at Brigham and Women's Hospital · NIH-11351995 · Data updated 2026-11-12
This project studies why aspirin-triggered respiratory disease happens and tests potential ways to reduce its airway inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2011 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,530,450 |
| NIH project number | 2U19AI095219-16 |
| Project ID | NIH-11351995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with aspirin-exacerbated respiratory disease or severe asthma with nasal polyps who may contribute tissue samples or participate in related studies.
✕Less likely to help
Patients without AERD or CRSwNP or those not contributing tissue samples may see no direct benefit.
What this research studies
If you have severe asthma with nasal polyps and aspirin sensitivity, this research looks at the cells and signals in your airways that drive the disease. Researchers are exploring how mast cells, TGF-beta, and other pathways contribute to ongoing inflammation and tissue changes. The work uses patient-derived tissues and animal models to understand the mechanisms and to identify targets for safer, more effective therapies. Findings could lead to new treatments that address the root causes of AERD and CRSwNP, not just symptoms.
Why it matters
Potential benefit: Could lead to new therapies that better control inflammation and improve breathing and nasal symptoms for people with AERD.
How similar studies have gone: Prior research has shown that targeting specific immune pathways can modify airway inflammation in similar diseases, with promising results in some patients.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Boyce, Joshua a — Brigham and Women's Hospital
- Study coordinator: Boyce, Joshua a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.