AI-powered pathology platform to personalize cancer therapy
Official title: An AI-enabled Digital Pathology Platform for Multi-Cancer Diagnosis, Prognosis and Prediction of Therapeutic Benefit
Funded at Emory University · NIH-11415799 · Data updated 2026-11-12
An AI-based tool analyzes patient tissue images to help doctors decide which cancer patients truly need or can skip certain chemotherapy or radiation treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 5, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $290,022 |
| NIH project number | 5U01CA269181-05 |
| Project ID | NIH-11415799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with various cancers where adjuvant chemotherapy or radiotherapy decisions are relevant, including settings with limited access to expensive prognostic tests.
✕Less likely to help
Patients whose tumors do not show the imaging patterns associated with de-escalated therapy could still require standard treatment.
What this research studies
This project uses digital pathology and computer vision to extract patterns from standard tissue slides that doctors can use to predict who will benefit from therapy and who may avoid unnecessary treatment. It aims to reduce over-treatment by offering more precise prognostic and predictive information, especially in settings with limited access to expensive tests. The work builds on existing multi-gene tests but focuses on affordable, image-based insights to guide therapy decisions across multiple cancer types.
Why it matters
Potential benefit: If successful, patients could receive more personalized treatment plans, avoiding unnecessary side effects while preserving outcomes.
How similar studies have gone: Prior digital pathology studies have shown that image patterns can correlate with outcomes and treatment responses in several cancers, supporting potential benefit for broader application.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Madabhushi, Anant — Emory University
- Study coordinator: Madabhushi, Anant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.