NIH-funded research NIH-funded research

AI-enhanced text messaging to help adults manage mental health symptoms

Official title: An AI-Enhanced Text Messaging Intervention for Self-Management of Mental Health Symptoms

Funded at Northwestern University · NIH-11330099 · Data updated 2026-11-12

A 4-year project from Northwestern uses automated text messages, boosted by AI, to help adults manage mood and anxiety and stay engaged with self-care strategies.

More Mental Health research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionNorthwestern University
NIH-funded
Lab location1 site (Chicago, United States)
Project startJuly 1, 2020
Project endJuly 31, 2031
Funding year2026
Award (this year)$428,777
NIH project number2P50MH119029-05A1
Project IDNIH-11330099 on NIH RePORTER

Who could benefit from this research

Could help

Adults 21+ with affective symptoms who are comfortable using text messaging and digital tools.

Less likely to help

Individuals without access to a mobile device or who prefer non-digital forms of support may not benefit.

What this research studies

This project builds on a 8-week text messaging program called Small Steps that guides adults in using proven techniques to manage mental health symptoms. By adding large language models to generate personalized, real-time replies, the program aims to keep users engaged and tailor support to individual needs. The study combines existing rule-based messaging with AI-generated dialogue, to improve fluency and relevance while maintaining safety and structure. Participants would interact with automated messages that encourage evidence-based self-management techniques in their everyday lives.

Why it matters

Potential benefit: If successful, adults with mental health symptoms could receive more personalized and timely support through familiar mobile messages.

How similar studies have gone: Previous DMHIs showed usability and symptom reduction, suggesting potential for benefit with improved AI personalization.

Where this research is happening

  • Northwestern University
    Chicago, United States
    Active

Researchers

  • Principal investigator: Kornfield, Rachel — Northwestern University
  • Study coordinator: Kornfield, Rachel

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.