Adipose MTP and FIT2: how fat tissue controls cholesterol, obesity, and heart disease

Who could benefit from this research

What this research studies

This project explores how two fat-tissue proteins, MTP and FIT2, influence lipid metabolism and inflammation that contribute to atherosclerosis. Researchers will study mice with altered MTP or FIT2 in adipose tissue to understand effects on body fat, liver fat, and artery disease, and will examine the mechanisms by which these proteins change lipase activity and lipid processing. The work combines mouse models with detailed molecular analyses to map how adipose tissue communicates with the liver and blood vessels in the context of ASCVD. The goal is to identify targets in fat tissue that could lower harmful lipids and reduce cardiovascular risk for people with atherosclerotic disease.

Why it matters

Where this research is happening

• New York University D/b/a NYU Long Island School of Medicine
  Mineola, United States Active

Researchers

• Principal investigator: Hussain, M Mahmood — New York University D/b/a NYU Long Island School of Medicine
• Study coordinator: Hussain, M Mahmood

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.