Understanding how certain proteins in fat tissue affect cholesterol levels and heart disease.
Adipose MTP and FIT2 in the regulation of plasma lipids, obesity and atherosclerosis
This study is looking at how two proteins, MTP and FIT2, affect fat storage and cholesterol levels, which could help us understand heart disease better, especially for people who are concerned about their heart health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project ID | NIH-11064052 on NIH RePORTER |
What this research studies
This research investigates the roles of two proteins, microsomal triglyceride transfer protein (MTP) and fat storage-inducing transmembrane protein 2 (FIT2), in fat tissue and their impact on cholesterol levels and heart disease. By studying mice with specific deficiencies in these proteins, the research aims to uncover how they influence fat storage, liver health, and the development of atherosclerosis. The approach includes examining the mechanisms by which these proteins affect lipid metabolism and inflammation, which are critical factors in cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with high cholesterol or obesity.
Not a fit: Patients who do not have issues related to lipid metabolism or cardiovascular health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cardiovascular diseases by targeting lipid metabolism.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism and its relation to cardiovascular diseases, indicating that this approach has potential for success.
Where this research is happening
Mineola, United States
- NYU Long Island School of Medicine — Mineola, United States (Active)
Researchers
- Principal investigator: Hussain, M Mahmood — NYU Long Island School of Medicine
- Study coordinator: Hussain, M Mahmood
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.