Understanding how certain proteins in fat tissue affect cholesterol levels and heart disease.

Who could benefit from this research

What this research studies

This research investigates the roles of two proteins, microsomal triglyceride transfer protein (MTP) and fat storage-inducing transmembrane protein 2 (FIT2), in fat tissue and their impact on cholesterol levels and heart disease. By studying mice with specific deficiencies in these proteins, the research aims to uncover how they influence fat storage, liver health, and the development of atherosclerosis. The approach includes examining the mechanisms by which these proteins affect lipid metabolism and inflammation, which are critical factors in cardiovascular health.

Why it matters

Where this research is happening

• NYU Long Island School of Medicine
  Mineola, United States Active

Researchers

• Principal investigator: Hussain, M Mahmood — NYU Long Island School of Medicine
• Study coordinator: Hussain, M Mahmood

Related research

Other NIH-funded projects on the same topics.

• Adipose MTP and FIT2: how fat tissue controls cholesterol, obesity, and heart disease

  A research team at NYU Langone studies how fat tissue proteins MTP and FIT2 influence cholesterol levels, obesity, and atherosclerosis in order to find new ways to prevent heart disease.

  NIH research New York University D/b/a NYU Long Island School of Medicine · Mineola, United States · NIH-11327664

• How beta-carotene affects vitamin A production related to heart disease and obesity

  This study is looking at how beta-carotene, a natural pigment found in foods like carrots, might help produce vitamin A and affect heart disease and obesity, using a special mouse model to see if it can reduce fat buildup and inflammation, which could lead to new treatments for these conditions.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-10563152

• Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

  This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

• Understanding how maternal and infant sleep and daily rhythms influence early appetite and obesity risk

  This project explores how infant sleep, circadian rhythms, and maternal-infant timing relate to early appetite patterns and the risk of obesity in the first year of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11628798

• Coronary disease and immune activation in people with HIV and tuberculosis coinfection

  This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.

  NIH research Emory University · Atlanta, United States · NIH-11618831

• GLP-1 receptor agonists as immune targets to treat asthma in lean and obese adults

  Aims to understand how GLP-1R‑agonist diabetes medicines may directly calm immune cells to reduce asthma in adults who are lean or obese.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11616517

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.