NIH-funded research R01 grant

Accelerated Resolution Therapy for grief in older caregivers

Official title: Accelerated Resolution Therapy for Early Maladaptive Grief: A Clinical Trial

Funded at Mayo Clinic Jacksonville · NIH-11298955 · Data updated 2026-11-12

A clinical trial tests a brief therapy called Accelerated Resolution Therapy to help older family caregivers cope with maladaptive grief after losing loved ones.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMayo Clinic Jacksonville
NIH-funded
Lab location1 site (Jacksonville, United States)
Project startMarch 15, 2023
Project endFebruary 29, 2028
Funding year2026
Award (this year)$657,515
NIH project number5R01AG077656-04
Project IDNIH-11298955 on NIH RePORTER

Who could benefit from this research

Could help

Older adult family caregivers of a seriously ill relative who are experiencing maladaptive grief.

Less likely to help

Caregivers not experiencing maladaptive grief or those unable to participate in therapy sessions may not benefit.

What this research studies

Older adult caregivers of seriously ill patients often experience maladaptive grief that harms health and immune function. This trial tests Accelerated Resolution Therapy, a brief, low-risk treatment, to see if it reduces grief symptoms and improves well-being. The study uses a double-blind, randomized design with two groups and includes measurements of cognitive processing and loss integration, plus a mixed-methods look at predictors of response. Participants will be recruited from two geographic locations and receive the intervention or a comparison condition over a defined period. Results could inform improvements in support for grieving caregivers and potentially prevent longer-term emotional distress.

Why it matters

Potential benefit: If successful, the therapy could lessen grief-related distress and protect health in older caregivers.

How similar studies have gone: Prior evidence supports ART for distress and trauma, with promising results suggesting potential applicability to maladaptive grief in caregivers.

Where this research is happening

  • Mayo Clinic Jacksonville
    Jacksonville, United States
    Active

Researchers

  • Principal investigator: Tofthagen, Cindy — Mayo Clinic Jacksonville
  • Study coordinator: Tofthagen, Cindy

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.