Epigenetic Test for Severe Spermatogenic Failure and Cancer Risks

Who could benefit from this research

What this research studies

This project develops an epigenetic diagnostic tool for men with non-obstructive azoospermia (NOA), a severe form of infertility. The test looks at DNA repair–related epigenetic changes, such as MSH5 epimutations, to identify those at higher risk for related health issues. If successful, doctors could use the test to inform prognosis, monitor health, and explore targeted therapies in the future. The work builds on prior findings and moves from discovery toward a Phase II SBIR product with clinical relevance. Participation would involve a blood or semen-derived sample and a clinical setting that supports CLIA-compliant testing.

Why it matters

Where this research is happening

• Inherent Biosciences, INC.
  Salt Lake City, United States Active

Researchers

• Principal investigator: Brogaard, Kristin R — Inherent Biosciences, INC.
• Study coordinator: Brogaard, Kristin R

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.