Condition

TP53 clinical trials and research

• 5Clinical trials
• 2Countries

Newest TP53 clinical trials

All recruiting trials (5)

• Glofitamab plus PD‑1 antibody and lenalidomide for relapsed/refractory TP53‑aberrant large B‑cell lymphoma

  This trial will test whether combining glofitamab with a PD‑1 antibody and lenalidomide can help adults with relapsed or refractory large B‑cell lymphoma that has TP53 mutations or deletions.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07240194

• Bortezomib combined with CPX-351 for newly diagnosed TP53‑mutated acute myeloid leukemia

  This trial tests whether adding the proteasome inhibitor bortezomib to CPX‑351 helps adults with newly diagnosed TP53‑mutated AML tolerate treatment and improve remission and survival.

  Recruiting Phase 1/2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT07008638

• Comparing Letrozole/Abemaciclib to Pembrolizumab for Endometrial Cancer Maintenance

  This study is testing whether a combination of letrozole and abemaciclib can help people with advanced or recurring endometrial cancer feel better compared to taking pembrolizumab alone after their initial chemotherapy.

  Recruiting at 6 sites Phase 2 Dana-Farber Cancer Institute · Aurora, Colorado and 7 other locations · NCT06366347

• Combining Azacitidine with R-CHOP for treating TP53-mutated DLBCL

  This study is testing if adding Azacitidine to the standard R-CHOP treatment can help people with untreated Diffuse Large B-cell Lymphoma who have TP53 mutations feel better and live longer.

  Recruiting Phase 2 The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT06158399

• T cell receptor depletion for blood cancer treatment

  This study is testing a new way to treat blood cancers by using a special treatment before a stem cell transplant to see if it helps both kids and adults do better after the procedure.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05735717

Related topics

Quick answers

How many TP53 clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (3 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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