Condition

Squamous Cell Carcinoma of the Head and Neck clinical trials and research

• 12Clinical trials
• 11Countries

Newest Squamous Cell Carcinoma of the Head and Neck clinical trials

All recruiting trials (12)

• Ficerafusp alfa plus pembrolizumab before surgery for resectable head and neck squamous cell carcinoma

  This trial will test whether giving ficerafusp alfa together with pembrolizumab before surgery helps people with PD‑L1–positive, resectable, high‑risk head and neck squamous cell carcinoma.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07465276

• Cisplatin-related (Ear) Hearing Loss and Balance Issues in Head and Neck Cancer Patients

  This observational study tests whether hearing loss, tinnitus, and balance problems occur in head and neck cancer patients treated with cisplatin chemoradiotherapy compared with those receiving only radiotherapy, including optional genetic tests for susceptibility.

  Recruiting Paracelsus Medical University · Nuremberg, Bavaria · NCT06929468

• Injecting a viral particle to treat head and neck cancer

  This study is testing a new virus injection to see if it can help treat head and neck cancer in different groups of patients.

  Recruiting Phase 1 VLP Therapeutics · Stanford, California · NCT06736379

• Understanding the mechanisms behind squamous cell carcinomas

  This study is trying to learn more about squamous cell carcinoma by looking at samples from patients to see how certain markers and cells affect the disease and its treatment.

  Recruiting at 4 sites National Cancer Institute, Naples · Bari, Bari and 3 other locations · NCT06236464

• Neoadjuvant chemotherapy with a vaccine for HPV-related throat cancer

  This study is testing if a new vaccine combined with standard chemotherapy can help people with HPV-related throat cancer live longer and avoid radiation treatment.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06223568

• MRG003 vs cetuximab/methotrexate for RM-SCCHN after prior therapies

  This trial tests whether MRG003 can help people with recurrent/metastatic squamous cell carcinoma of the head and neck who have already tried PD-1 inhibitors and platinum therapy by comparing it to cetuximab plus methotrexate as a later-line treatment.

  Recruiting Phase 3 Lepu Biopharma Co., Ltd. · Shanghai, Shanghai Municipality · NCT05751512

• Modi-1 vaccine for advanced cancers

  This study is testing a new vaccine for people with advanced cancers like triple negative breast cancer and ovarian cancer to see if it can boost their immune response and work better with other treatments.

  Recruiting at 13 sites Phase 1/2 Scancell Ltd · Brighton, Default and 15 other locations · NCT05329532

• Testing a new drug for advanced solid tumors

  This study is testing a new drug for people with advanced solid tumors, like lung and head and neck cancers, to see if it works better when combined with another treatment after other options have failed.

  Recruiting at 62 sites Phase 1 Seagen Inc. · Birmingham, Alabama and 61 other locations · NCT05208762

• Observing cancer recurrence using a blood test

  This study is testing a new blood test to see if it can help find out if cancer comes back in people who have been treated for early-stage solid tumors.

  Recruiting at 49 sites Guardant Health, Inc. · Birmingham, Alabama and 56 other locations · NCT05059444

• Evaluating the safety and effectiveness of ST-067 in treating various solid tumors

  This study is testing a new treatment called ST-067 to see if it can help people with tough-to-treat solid tumors feel better and improve their health.

  Recruiting at 6 sites Phase 1/2 Simcha IL-18, Inc. · Scottsdale, Arizona and 5 other locations · NCT04787042

• Creating patient-derived tumor models for head and neck cancer

  This study is trying to collect tumor samples from patients with head and neck cancer to create models that help test new treatments and understand how these tumors respond to them.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT02572778

• Collecting plasma samples from patients with head and neck squamous cell carcinoma

  This study is collecting blood samples from patients with head and neck cancer to see if certain markers can help predict how well treatments like cetuximab will work for them.

  Recruiting at 5 sites Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Ottignies, Brabant Wallon and 4 other locations · NCT02139020

Related topics

Quick answers

How many Squamous Cell Carcinoma of the Head and Neck clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (6 trials), Germany (3 trials), Italy (3 trials), Belgium (3 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 2, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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