Condition

Severe Aortic Stenosis clinical trials and research

• 11Clinical trials
• 4NIH research projects
• 9Countries

Newest Severe Aortic Stenosis clinical trials

All recruiting trials (11)

• Registry of Transcatheter Aortic Valve Treatments at a Italian Center

  This registry tests how safe and effective transcatheter valve procedures are in adults with severe aortic stenosis treated at a single Italian center.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT07596394

• CT-FFR-guided revascularization for people with severe aortic stenosis

  This study will see if adding CT-FFR (a noninvasive blood-flow test) to preoperative CT angiography helps doctors decide whether people with severe aortic stenosis need coronary revascularization before valve replacement.

  Recruiting Yan'an Affiliated Hospital of Kunming Medical University · Kunming, Yunnan · NCT07469371

• RENATUS transcatheter aortic valve for severe aortic stenosis

  This trial tests the RENATUS transcatheter aortic valve in people with symptomatic severe aortic stenosis who are eligible for TAVR.

  Recruiting at 4 sites Beijing Balance Medical Technology Co., Ltd · Beijing and 3 other locations · NCT07414342

• Pre-emptive LAVA-ECMO support for complex, high-risk TAVR

  The team will try pre-emptive left atrial veno-arterial ECMO to stabilize adults with severe aortic stenosis undergoing complex, high-risk TAVR who are unstable or at risk of instability.

  Recruiting at 2 sites Atlantic Health System · Detroit, Michigan and 1 other locations · NCT07309029

• Comparing the DurAVR transcatheter heart valve with SAPIEN and Evolut valves for severe aortic stenosis

  This trial will test whether the DurAVR transcatheter heart valve works as well and is as safe as SAPIEN or Evolut valves in people with severe calcific aortic stenosis, and it also includes a registry for people needing valve‑in‑valve procedures.

  Recruiting Anteris Technologies Ltd. · Copenhagen, Capital Region of Denmark · NCT07194265

• Navitor TAVI valve in Japanese patients with severe aortic stenosis

  This study will try the Navitor transcatheter aortic valve with the FlexNav delivery system in about 100 Japanese adults with symptomatic severe aortic stenosis to track safety and how well the valve works.

  Recruiting at 3 sites Abbott Medical Devices · Fukuoka and 2 other locations · NCT07193888

• Improving quality of life for patients with severe aortic stenosis

  This study looks at how severe aortic stenosis affects the daily lives of patients to see if a new heart valve procedure can help improve their quality of life.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 3 other locations · NCT06477042

• Evaluating a new heart valve system for patients with severe aortic stenosis

  This study is testing a new heart valve system to see if it can safely help older patients with severe aortic stenosis who can’t have regular surgery.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT06136429

• Comparing aspirin and clopidogrel after heart valve replacement

  This study is testing whether taking aspirin or clopidogrel alone after heart valve replacement helps prevent blood clots in patients with severe aortic stenosis.

  Recruiting Yonsei University · Seoul · NCT05493657

• Assessing the safety and performance of a new transcatheter aortic valve

  This study tests a new heart valve for people with severe aortic stenosis who can't have traditional surgery to see if it is safe and works well.

  Recruiting Thubrikar Aortic Valve, Inc. · Krakow · NCT04076150

• Colibri Transcatheter Aortic Heart Valve System for severe aortic stenosis

  This study is testing a new heart valve system to see if it can safely help older patients with severe aortic stenosis who are at high risk for surgery.

  Recruiting at 5 sites Colibri Heart Valve LLC · Lille and 4 other locations · NCT04029844

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Aortic valve calcium and risk of severe aortic stenosis in people over 75

  This project looks at how common calcium on the aortic valve is in people over 75 and which factors make it more likely to progress to severe aortic narrowing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11252602

• Predicting heart changes to improve care for women with severe aortic stenosis

  This project uses advanced medical imaging and computer models to better predict how women's hearts remodel from severe aortic stenosis so care can be more personalized.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11175320

• Investigating aortic valve calcium and its risks in older adults

  This study is looking at how common aortic valve calcification is in people aged 75 and older and how it might lead to serious heart problems, with the goal of finding ways to help those at higher risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11045115

• Understanding how women's bodies respond to severe aortic stenosis to improve treatment outcomes

  This study is looking at how severe aortic stenosis affects women differently than men, with the hope of creating better, personalized treatment plans for women to improve their heart valve replacement procedures.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10870456

Related topics

Quick answers

How many Severe Aortic Stenosis clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in China (3 trials), France (2 trials), United States (1 trial), South Korea (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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