Condition

Richter Transformation clinical trials and research

• 6Clinical trials
• 1New in 30 days
• 19Countries

Newest Richter Transformation clinical trials

All recruiting trials (6)

• Pirtobrutinib and Epcoritamab vs R-(Mini)-CHOP for DLBCL-type Richter Transformation in older or frail adults

  This trial tests a fixed-duration treatment with Pirtobrutinib and Epcoritamab against a mini-CHOP regimen in adults age 80+ or who are frail with Richter transformation.

  Recruiting at 7 sites Phase 2 German CLL Study Group · Melbourne and 11 other locations · NCT07917780

• Evaluating NX-1607 for advanced cancers

  This study is testing a new treatment called NX-1607 to see if it can help people with advanced cancers who have run out of other options.

  Recruiting at 15 sites Phase 1 Nurix Therapeutics, Inc. · Duarte, California and 16 other locations · NCT05107674

• Exploring BGB-16673 for treating B-cell malignancies

  This study is testing a new drug called BGB-16673 to see if it can safely help people with certain types of B-cell cancers, like Marginal Zone Lymphoma and Follicular Lymphoma, who haven't had success with other treatments.

  Recruiting at 104 sites Phase 1/2 BeOne Medicines · Birmingham, Alabama and 113 other locations · NCT05006716

• CAR-T cell therapy for relapsed or refractory DLBCL

  This study is testing a new CAR-T cell therapy to see if it can help people with tough-to-treat diffuse large B cell lymphoma feel better after other treatments haven’t worked.

  Recruiting at 30 sites Phase 2 Miltenyi Biomedicine GmbH · Birmingham, Alabama and 31 other locations · NCT04792489

• Oral treatment with LP-118 for patients with various blood cancers

  This study is testing a new oral treatment called LP-118 to see if it is safe and can help people with certain types of blood cancers that have come back or didn’t respond to other treatments.

  Recruiting at 8 sites Phase 1 Newave Pharmaceutical Inc · Chicago, Illinois and 7 other locations · NCT04771572

• Combining zanubrutinib and tislelizumab for treating Richter Transformation

  This study is testing a new combination of two drugs, zanubrutinib and tislelizumab, to see if they can help people with Richter Transformation, a serious complication of chronic lymphocytic leukemia, when other treatments haven't worked.

  Recruiting at 10 sites Phase 2 German CLL Study Group · Vienna and 10 other locations · NCT04271956

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Quick answers

How many Richter Transformation clinical trials are recruiting right now?

6, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (4 trials), Germany (3 trials), United Kingdom (2 trials), Australia (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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