Condition

Recurrent Astrocytoma, IDH-Mutant, Grade 4 clinical trials and research

• 5Clinical trials
• 1Country

Newest Recurrent Astrocytoma, IDH-Mutant, Grade 4 clinical trials

All recruiting trials (5)

• Locally delivered EGFR/IL13Rα2 CAR T-cell therapy for recurrent high-grade gliomas

  This phase I study tests whether a patient's own EGFR/IL13Rα2 CAR T cells, given directly into the brain, are safe and can help adults with recurrent or progressive high-grade gliomas.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT07544992

• GI-102 With or Without Pembrolizumab Before Surgery for Recurrent or Progressive Grade 4 Gliomas

  The team will test whether giving GI-102 alone or together with pembrolizumab before surgery helps adults with recurrent or progressive IDH‑wildtype glioblastoma or IDH‑mutant grade 4 astrocytoma.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07301268

• Adding triapine to radiation therapy for recurrent glioblastoma and astrocytoma

  This early-phase study tests whether giving the drug triapine together with radiation is safe and tolerable for adults whose glioblastoma or astrocytoma has come back.

  Recruiting at 36 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 42 other locations · NCT06860594

• Using genetically modified immune cells to treat recurrent brain tumors

  This study is testing a new treatment using modified immune cells to see if it can help people with recurring brain tumors feel better and fight their cancer.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06815029

• Using fat-derived stem cells to treat recurrent brain tumors during surgery

  This study is testing whether injecting fat-derived stem cells directly into the brain during surgery can help people with recurrent brain tumors feel better and live longer.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT05789394

Related topics

Quick answers

How many Recurrent Astrocytoma, IDH-Mutant, Grade 4 clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →