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Phase 1 clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Phase 1 clinical trials that are recruiting, in United States. By phase: Phase 1 (4). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 1Country
Newest Phase 1 clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Engineered NK Cells with dual CARs for recurrent glioblastoma | Phase 1 | Houston, Texas | Recruiting | May 12, 2026 |
| SAR445877 with FOLFOX6 and bevacizumab as first-line treatment for MSS metastatic colorectal cancer | Phase 1 | Houston, Texas | Recruiting | Mar 30, 2026 |
| Allogeneic TGFBR2‑knockout CD70 CAR NK cell therapy for refractory clear cell renal cell carcinoma | Phase 1 | Houston, Texas | Recruiting | Jul 18, 2025 |
| Testing a new treatment using engineered NK cells for advanced melanoma | Phase 1 | Houston, Texas | Recruiting | Oct 28, 2024 |
All recruiting trials (4)
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Engineered NK Cells with dual CARs for recurrent glioblastoma
This study tests whether delivering specially engineered natural killer (NK) cells to glioblastoma patients is safe and helps fight the tumor, using three different administration routes to find the best approach.
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SAR445877 with FOLFOX6 and bevacizumab as first-line treatment for MSS metastatic colorectal cancer
This study tests whether giving SAR445877 together with FOLFOX6 and bevacizumab is safe and tolerable as a first-line treatment for adults with MSS metastatic colorectal cancer.
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Allogeneic TGFBR2‑knockout CD70 CAR NK cell therapy for refractory clear cell renal cell carcinoma
This will test donor-derived TGFBR2‑knockout CD70 CAR NK cells given after lymphodepleting chemotherapy in adults with metastatic or unresectable clear cell renal cell carcinoma who progressed after immune checkpoint inhibitors and tyrosine kinase inhibitors.
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Testing a new treatment using engineered NK cells for advanced melanoma
This study is testing a new treatment using specially engineered immune cells to see if it can help people with advanced melanoma who haven't responded to other treatments.
Related topics
Quick answers
How many Phase 1 clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.