Condition

Pancreatic Adenocarcinoma Metastatic clinical trials and research

• 9Clinical trials
• 21Countries

Newest Pancreatic Adenocarcinoma Metastatic clinical trials

All recruiting trials (9)

• Zoldonrasib plus Daraxonrasib vs Gemcitabine and Nab-Paclitaxel as first-line treatment for metastatic KRAS G12D pancreatic cancer

  This study tests whether two investigational RAS inhibitors together can improve outcomes compared with standard chemotherapy in adults with newly diagnosed metastatic pancreatic cancer carrying the KRAS G12D mutation.

  Recruiting at 6 sites Phase 3 Revolution Medicines, Inc. · Phoenix, Arizona and 5 other locations · NCT07805954

• Metabolic and Microenvironment Patterns in Metastatic Pancreatic Cancer

  Researchers are testing how metabolism and surrounding cells in pancreatic cancer relate to treatment responses, using biopsies and blood samples from patients with metastatic disease.

  Recruiting Institut Paoli-Calmettes · Marseille · NCT07664891

• Zoldonrasib + chemotherapy vs placebo + chemotherapy as first-line treatment for metastatic KRAS G12D pancreatic cancer

  This trial tests whether adding zoldonrasib to standard chemotherapy helps people with newly diagnosed metastatic KRAS G12D pancreatic cancer.

  Recruiting at 25 sites Phase 3 Revolution Medicines, Inc. · Phoenix, Arizona and 24 other locations · NCT07621718

• Atebimetinib plus gemcitabine and nab‑paclitaxel as first‑line treatment for metastatic pancreatic cancer

  This trial will test whether adding the MAPK pathway drug atebimetinib to gemcitabine and nab‑paclitaxel helps people with newly diagnosed metastatic pancreatic ductal adenocarcinoma live longer.

  Recruiting at 76 sites Phase 3 Immuneering Corporation · Huntsville, Alabama and 75 other locations · NCT07562152

• Daraxonrasib alone or with gemcitabine and nab-paclitaxel for first-line metastatic pancreatic cancer

  This trial will see if daraxonrasib, alone or with gemcitabine and nab-paclitaxel, helps people with newly diagnosed metastatic pancreatic cancer live longer or slow tumor growth compared with standard gemcitabine and nab-paclitaxel.

  Recruiting at 61 sites Phase 3 Revolution Medicines, Inc. · Phoenix, Arizona and 81 other locations · NCT07491445

• OMTX705 added to standard chemo with or without tislelizumab for advanced pancreatic cancer

  This trial will try adding OMTX705 to gemcitabine/nab‑paclitaxel, with or without tislelizumab, to see if it is safe and might help people with advanced or metastatic pancreatic cancer.

  Recruiting at 6 sites Phase 1 Oncomatryx Biopharma S.L. · Boston, Massachusetts and 6 other locations · NCT07377045

• TTFields plus modFOLFIRINOX for metastatic pancreatic adenocarcinoma

  This trial will test whether adding Tumor Treating Fields (TTFields) to modFOLFIRINOX chemotherapy is safe, tolerable, and helpful for adults with metastatic pancreatic ductal adenocarcinoma.

  Recruiting Phase 1/2 Clinica Universidad de Navarra, Universidad de Navarra · Pamplona, Navarre and 4 other locations · NCT07284277

• Combining Niraparib and Ipilimumab for Metastatic Pancreatic Cancer Treatment

  This study is testing if combining two treatments, niraparib and ipilimumab, can help people with metastatic pancreatic cancer whose disease hasn't worsened after chemotherapy.

  Recruiting at 2 sites Phase 2 Abramson Cancer Center at Penn Medicine · Boston, Massachusetts and 1 other locations · NCT06747845

• Treatment for metastatic cancer with BRCA or PALB2 mutations using chemotherapy and stem cells

  This study is testing a new treatment combining chemotherapy and stem cells for people with metastatic pancreatic or breast cancer who have BRCA or PALB2 mutations to see if it is safe and effective.

  Recruiting Phase 1 General Oncology, Inc. · Boston, Massachusetts and 1 other locations · NCT04150042

Related topics

Quick answers

How many Pancreatic Adenocarcinoma Metastatic clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (7 trials), Spain (4 trials), United Kingdom (3 trials), Australia (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 1: 2, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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