Condition

NPM1 Mutation clinical trials and research

• 6Clinical trials
• 4Countries

Newest NPM1 Mutation clinical trials

All recruiting trials (6)

• Menin inhibitor maintenance after allogeneic stem cell transplant

  This project will try menin inhibitor maintenance to see if it helps people with acute leukemia after allogeneic stem cell transplant who have KMT2A or related gene changes.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07559695

• BN104 maintenance after allogeneic stem cell transplant for acute leukemia

  This trial tests whether taking the oral menin inhibitor BN104 can reduce relapse in people with acute leukemia who have specific genetic changes and are 1–6 months after an allogeneic stem cell transplant.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07101497

• APL-like A Cute Myeloid Leukemia in NPM1-M mutated patients: distinctive features and early vascular events

  This observational study tests whether an APL-like appearance in NPM1-mutated AML can predict early clotting problems and vascular events.

  Recruiting Gruppo Italiano Malattie EMatologiche dell'Adulto · Florence · NCT07080970

• Ziftomenib treatment after blood cancer transplant

  This study is testing if ziftomenib can help people with acute myeloid leukemia feel better and stay healthy after a blood cancer transplant.

  Recruiting at 2 sites Phase 1 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06440135

• Examining the safety of ziftomenib combinations for patients with relapsed acute myeloid leukemia

  This study is testing if combining ziftomenib with standard treatments can safely help people with relapsed acute myeloid leukemia feel better and improve their chances of recovery.

  Recruiting at 43 sites Phase 1 Kura Oncology, Inc. · Gilbert, Arizona and 44 other locations · NCT06001788

• Investigating Ziftomenib with Other Treatments for Acute Myeloid Leukemia

  This study is testing if a new drug called ziftomenib, when combined with other treatments, can help people with acute myeloid leukemia who have certain genetic mutations feel better and stay safe during treatment.

  Recruiting at 44 sites Phase 1 Kura Oncology, Inc. · Phoenix, Arizona and 43 other locations · NCT05735184

Related topics

Quick answers

How many NPM1 Mutation clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (3 trials), China (2 trials), Italy (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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