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Nasopharyngeal Carcinoma (NPC) clinical trials and research

• 26Clinical trials
• 1New in 30 days
• 4Countries

Newest Nasopharyngeal Carcinoma (NPC) clinical trials

All recruiting trials (26)

• Structured swallowing exercises for nasopharyngeal cancer patients

  This trial tests whether a structured swallowing exercise program improves swallowing and quality of life more than conventional swallowing exercises in adults with nasopharyngeal carcinoma.

  Recruiting Universitas Indonesia · Jakarta Pusat, DKI Jakarta · NCT07909538

• Dynamic risk prediction for severe blood cell suppression in nasopharyngeal cancer

  This study tests a dynamic risk model to see if it can predict grade 3 or higher anemia, low platelets, or low white blood cells during systemic therapy for adults with nasopharyngeal cancer.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07819656

• Becotatug Vedotin plus PD-1 inhibitor for locally recurrent nasopharyngeal carcinoma

  This study tests whether adding becotatug vedotin to a PD-1 inhibitor helps people with locally recurrent nasopharyngeal cancer.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07781358

• Dynamic risk-guided EBV-DNA and MRI-based chemotherapy adjustments in nasopharyngeal carcinoma

  This trial tests whether adjusting adjuvant therapy based on changes in EBV DNA and MRI findings after radiotherapy helps improve outcomes for people with nasopharyngeal carcinoma.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07762976

• Immune Sandwich: Induction with Nimotuzumab and Toripalimab Plus Radiotherapy vs Full-Course Immunotherapy for Advanced Nasopharyngeal Cancer

  This trial tests whether a shortened, targeted immunotherapy plan added to chemoradiation can match the full immunotherapy approach for locally advanced nasopharyngeal cancer in adults 18–70.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT07706985

• RAIRI-guided risk-stratified adjuvant therapy after chemoradiotherapy in nasopharyngeal carcinoma

  This real-world study tests whether the RAIRI model can predict who will benefit from adjuvant therapy after chemoradiotherapy for non-metastatic nasopharyngeal carcinoma.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT07618078

• RAIRI-guided adjuvant therapy in nasopharyngeal carcinoma

  This trial tests whether using the RAIRI risk model to guide adjuvant therapy after chemoradiotherapy can spare some patients unnecessary treatment in locoregionally advanced nasopharyngeal carcinoma.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT07590024

• Taurine to help prevent and treat mouth ulcers from radiation in NPC

  This study tests whether taurine can help prevent and lessen severe radiation-induced oral mucositis in adults with newly diagnosed nasopharyngeal carcinoma receiving radiotherapy.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07567742

• Becotatug vedotin plus sintilimab with chemoradiation for high-risk nasopharyngeal carcinoma

  This trial tests whether adding becotatug vedotin before treatment and giving sintilimab with chemoradiation helps people with high‑risk locally advanced nasopharyngeal carcinoma live longer and avoid recurrence.

  Recruiting Phase 3 First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi · NCT07459296

• Proton versus photon radiation for advanced nasopharyngeal cancer

  This trial will test whether proton radiation (IMPT) or standard photon IMRT causes fewer severe side effects and improves 3-year progression-free survival for adults with newly diagnosed, high-risk locally advanced nasopharyngeal cancer who receive induction chemotherapy followed by concurrent chemoradiotherapy with i

  Recruiting Phase 3 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT07340515

• Lower-dose versus standard-dose radiation with concurrent chemoimmunotherapy for advanced nasopharyngeal cancer after a strong response to induction treatment

  This trial tests whether giving lower-dose radiation alongside ongoing chemotherapy and immunotherapy works as well as standard-dose radiation for people with locally advanced nasopharyngeal cancer who had a strong response and undetectable EBV DNA after induction chemoimmunotherapy.

  Recruiting at 12 sites Phase 3 Sun Yat-sen University · Guangzhou, Guangdong and 11 other locations · NCT07328841

• Sapylin versus inhaled dexamethasone to prevent painful mouth sores during chemoradiation for nasopharyngeal cancer

  This trial will test whether Sapylin given as an inhaled spray works better than inhaled dexamethasone at preventing or reducing radiation-induced mouth sores in adults with stage III–IVA nasopharyngeal cancer receiving concurrent chemoradiation with cisplatin.

  Recruiting Phase 3 Affiliated Hospital of Guangdong Medical University · Zhanjiang, Guangdong · NCT07327216

• Individualized neck irradiation for nasopharyngeal carcinoma

  This trial will test whether tailoring how far the neck is radiated based on each patient's lymph node spread works as well as standard broader neck radiation for adults with newly diagnosed, non-metastatic nasopharyngeal carcinoma.

  Recruiting at 2 sites Phase 3 Fudan University · Shanghai, Shanghai Municipality and 5 other locations · NCT07303023

• High-low dose radiation plus anti-PD-1 followed by full-course radiation for recurrent nasopharyngeal cancer

  This approach tests whether a short induction of mixed low- and high-dose radiation with an anti-PD-1 drug, followed by full-course radiation and immunotherapy maintenance, can shrink recurrent nasopharyngeal cancer in patients who cannot have surgery.

  Recruiting Phase 2 Jiangxi Provincial Cancer Hospital · Nanchang, Jiangxi · NCT07277764

• Reduced-target versus full-target IMRT after chemo and immunotherapy for metastatic nasopharyngeal cancer

  This trial will test whether smaller (reduced-target) radiotherapy after first-line chemo plus immunotherapy works as well as standard full-target radiotherapy for people with newly diagnosed distant metastatic nasopharyngeal cancer who responded to initial treatment.

  Recruiting Phase 3 Sun Yat-sen University · Zhuhai · NCT07188584

• Precise Guidance of Adaptive Radiotherapy for Nasopharyngeal Carcinoma

  This study uses PET/CT imaging with two tracers to see if they can better stage NPC and predict early response to neoadjuvant immunotherapy in adults with newly diagnosed NPC.

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen · NCT07137052

• Toripalimab with induction chemo, radiation, and Omega-3 for locally advanced nasopharyngeal cancer

  This study tests whether adding toripalimab and Omega-3 to induction chemotherapy and radiation helps patients with locally advanced nasopharyngeal carcinoma.

  Recruiting at 2 sites Phase 2 Affiliated Hospital of Guangdong Medical University · Zhanjiang, Guangdong and 2 other locations · NCT07136519

• Iparomlimab and Tuvonralimab plus nimotuzumab for recurrent or metastatic nasopharyngeal carcinoma after first-line treatment failure

  This will try combining two immune-targeting drugs, iparomlimab and tuvonralimab, with the antibody nimotuzumab to see if it helps people with recurrent or metastatic nasopharyngeal cancer whose first-line cisplatin-based treatment has failed.

  Recruiting Phase 2 Sun Yat-sen University · Guangdong · NCT07101744

• Nutritional management during chemoradiotherapy for nasopharyngeal cancer

  This study will test whether an immune‑enhancing oral nutritional supplement given throughout concurrent chemoradiotherapy helps adults with stage II–IVa nasopharyngeal cancer maintain weight, preserve lymphocyte counts, and reduce treatment side effects.

  Recruiting Phase 2 Jiangxi Provincial Cancer Hospital · Nanchang, Jiangxi · NCT07085988

• International registry for very rare childhood tumors

  This project will collect detailed medical information to see how clinical and biological features affect outcomes in children and adolescents with very rare tumors.

  Recruiting Azienda Ospedaliera di Padova · Padova, Italy · NCT07072143

• SSTR2 PET/CT imaging with 68Ga-DOTA-TOC for nasopharyngeal cancer

  We will test whether 68Ga‑DOTA‑TOC PET/CT scans can detect SSTR2 in adults with EBV‑positive nasopharyngeal cancer before and three weeks after starting chemotherapy or chemoradiotherapy.

  Recruiting Phase 1/2 University Medical Center Groningen · Groningen · NCT06982300

• Optimizing screening methods for nasopharyngeal carcinoma using EBV biomarkers

  This study is testing new ways to screen for nasopharyngeal cancer using blood tests for certain virus markers to see if they work better than the current methods for people at high risk.

  Recruiting Sun Yat-sen University · Zhuhai, Guangdong · NCT06870435

• HLX43 for recurrent or metastatic nasopharyngeal carcinoma after multiple prior treatments

  This trial will test whether the anti‑PD‑L1 antibody–drug conjugate HLX43 can help adults with recurrent or metastatic nasopharyngeal carcinoma who have not responded to or cannot tolerate at least two prior systemic therapies including prior PD‑1/PD‑L1 treatment.

  Recruiting at 15 sites Phase 2 Shanghai Henlius Biotech · Fuzhou, Fujian and 14 other locations · NCT06839066

• Hypofractionated radiotherapy for nasopharyngeal carcinoma

  This study is testing a new type of radiation treatment for nasopharyngeal cancer to see if it works better and is safer than the usual methods.

  Recruiting The Second Affiliated Hospital of Hainan Medical University · Haikou, Hainan · NCT06796270

• NPC Screening Cohort in South China

  This study tests a comprehensive screening approach to identify nasopharyngeal carcinoma in adults aged 30-69 who live in NPC-endemic regions by combining EBV tests, questionnaires, and clinical exams.

  Recruiting Sun Yat-sen University · Zhuhai, Guangdong · NCT06787456

• Combining nab-paclitaxel with radiation therapy for advanced nasopharyngeal carcinoma

  This study is testing different doses of nab-paclitaxel combined with radiation therapy to see if it can help people with advanced nasopharyngeal cancer feel better and improve their treatment outcomes.

  Recruiting Phase 1 Sun Yat-sen University · Guangzhou, Guangdong · NCT06611150

Related topics

Quick answers

How many Nasopharyngeal Carcinoma (NPC) clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (23 trials), Indonesia (1 trial), Italy (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 3: 8, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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