Condition

Malignant Primary Gliomas clinical trials and research

• 2Clinical trials
• 1Country

All recruiting trials (2)

• Paxalisib plus temozolomide for malignant brain tumours with PI3K pathway changes

  This trial tests whether adding paxalisib to standard temozolomide helps people with newly diagnosed MGMT-unmethylated glioblastoma whose tumors have PI3K-activating mutations or PTEN loss.

  Recruiting Phase 1/2 Institute of Cancer Research, United Kingdom · Sutton · NCT07391215

• Combination therapy for malignant brain tumors using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help people with advanced malignant brain tumors like glioblastoma feel better and improve their treatment options.

  Recruiting at 3 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Cambridge and 2 other locations · NCT06630260

Related topics

Quick answers

How many Malignant Primary Gliomas clinical trials are recruiting right now?

2, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United Kingdom. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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