Condition
Locally Advanced Rectal Adenocarcinoma clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Locally Advanced Rectal Adenocarcinoma clinical trials that are recruiting, at sites in 2 countries (most in United States (3), China (1)). By phase: Phase 2 (3), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 2Countries
Newest Locally Advanced Rectal Adenocarcinoma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Simultaneous GTV Dose Boost with Neoadjuvant Radiotherapy for Locally Advanced Rectal Cancer | Phase 2 | Beijing | Recruiting | Sep 30, 2025 |
| Combination treatment for rectal adenocarcinoma using botensilimab and balstilimab | Phase 2 | Basking Ridge, New Jersey and 6 other locations | Recruiting | Feb 25, 2025 |
| Papaverine combined with radiation therapy for advanced rectal cancer | Phase 1 | Duarte, California | Recruiting | Feb 19, 2025 |
| Combining Tucatinib and Trastuzumab for HER2 Positive Rectal Cancer | Phase 2 | Basking Ridge, New Jersey and 6 other locations | Recruiting | Jan 5, 2023 |
All recruiting trials (4)
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Simultaneous GTV Dose Boost with Neoadjuvant Radiotherapy for Locally Advanced Rectal Cancer
In adults with locally advanced rectal adenocarcinoma, this study tests whether boosting the GTV to 58.75 Gy before surgery improves tumor response compared with the standard 50 Gy, when given with chemoradiation.
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Combination treatment for rectal adenocarcinoma using botensilimab and balstilimab
This study is testing a new combination treatment with botensilimab and balstilimab to see if it can help people with locally advanced rectal cancer feel better with fewer side effects than regular chemotherapy.
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Papaverine combined with radiation therapy for advanced rectal cancer
This study is testing if adding papaverine to radiation therapy can help people with advanced rectal cancer feel better and improve their treatment results.
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Combining Tucatinib and Trastuzumab for HER2 Positive Rectal Cancer
This study is testing if combining two cancer drugs, tucatinib and trastuzumab, with standard chemotherapy can help people with HER2 positive rectal cancer have better treatment results.
Related topics
Quick answers
How many Locally Advanced Rectal Adenocarcinoma clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (3 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.