Condition

Locally Advanced Head and Neck Squamous Cell Carcinoma clinical trials and research

• 13Clinical trials
• 23Countries

Newest Locally Advanced Head and Neck Squamous Cell Carcinoma clinical trials

All recruiting trials (13)

• Sintilimab Plus Hypofractionated Radiotherapy Then Chemoradiotherapy for Locally Advanced Head and Neck Cancer

  This study tests whether giving sintilimab with a short, high-dose radiotherapy course followed by standard chemoradiotherapy helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07781072

• Omitting Postoperative Cervical Radiation in Select Head and Neck Cancer Patients

  We’re testing whether leaving out some neck radiation after surgery is safe and could reduce side effects for adults with locally advanced head and neck squamous cell carcinoma who had neck dissections and no high-risk nodal factors.

  Recruiting Phase 2 Institut Català d'Oncologia · L'Hospitalet de Llobregat, Barcelona · NCT07755449

• Becotatug vedotin plus PD-1 inhibitor versus PD-1 inhibitor alone for EGFR‑positive resectable locally advanced head and neck cancer

  This trial will test if adding becotatug vedotin to a PD‑1 blocker given before and after surgery helps people with EGFR‑positive, CPS≥1 resectable locally advanced head and neck cancer do better than a PD‑1 blocker alone.

  Recruiting Phase 3 Sun Yat-sen University · Zhuhai, Guangdong · NCT07524452

• Low-dose radiotherapy plus anti–PD-1 immunotherapy before surgery for resectable locally advanced head and neck cancer

  This will test whether giving low-dose radiation together with two cycles of an anti–PD‑1 drug before surgery helps people with resectable locally advanced head and neck squamous cell carcinoma (CPS ≥1).

  Recruiting Phase 2 Fifth Affiliated Hospital, Sun Yat-Sen University · Guangdong · NCT07371234

• Comparing smaller, targeted surgery versus standard surgery after pre-surgery immunotherapy for locally advanced head and neck cancer

  This trial tests whether smaller, response-guided surgery instead of the usual larger operation after neoadjuvant PD-1‑based chemoimmunotherapy works for people with resectable locally advanced head and neck squamous cell carcinoma who had a partial or complete response.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07369882

• MRG003 alone or with the PD‑1 drug pucotenlimab before chemoradiotherapy for locally advanced head and neck squamous cell carcinoma

  This trial will test whether giving MRG003 alone or together with the PD‑1 drug pucotenlimab before standard chemoradiotherapy helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Groupe Oncologie Radiotherapie Tete et Cou · Villejuif · NCT06959108

• De-escalation radiation strategy for advanced head and neck cancer

  This study is testing a new treatment plan for people with advanced head and neck cancer to see if combining immunotherapy with chemotherapy before radiation can help them avoid more intense surgery later on.

  Recruiting Phase 1/2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06572514

• Combination therapy for advanced oral squamous cell carcinoma

  This study is testing a new combination of treatments for people with advanced oral cancer to see if it helps them do better before surgery.

  Recruiting Phase 2 Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality · NCT06470217

• Maintenance therapy with Sintilimab after chemoradiotherapy for advanced head and neck cancer

  This study is testing if a new treatment called Sintilimab can help people with advanced head and neck cancer stay healthier after their initial therapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06240689

• Evaluating volrustomig for advanced head and neck cancer after chemoradiotherapy

  This study is testing if a new treatment called volrustomig can help people with advanced head and neck cancer who haven't seen their disease get worse after previous treatment.

  Recruiting at 252 sites Phase 3 AstraZeneca · Birmingham, Alabama and 305 other locations · NCT06129864

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining Ipatasertib with Chemotherapy and Radiation for Head and Neck Cancer

  This study is testing if adding a new drug called ipatasertib to chemotherapy and radiation can help people with advanced head and neck cancer feel better and improve their treatment results.

  Recruiting at 13 sites Phase 1 National Cancer Institute (NCI) · Tampa, Florida and 17 other locations · NCT05172245

• Comparing low-dose and high-dose cisplatin for head and neck cancer treatment

  This study is testing whether giving lower doses of cisplatin can help people with advanced head and neck cancer avoid serious side effects, like hearing loss, while still getting effective treatment.

  Recruiting at 2 sites London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Hamilton, Ontario and 2 other locations · NCT03649048

Related topics

Quick answers

How many Locally Advanced Head and Neck Squamous Cell Carcinoma clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in China (8 trials), Canada (3 trials), United States (3 trials), France (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 2, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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