Condition
Hypophosphatasia clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Hypophosphatasia clinical trials that are recruiting, at sites in 4 countries (most in United States (3), Russia (1), France (1)). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 4Countries
Newest Hypophosphatasia clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| How a single ALPL gene change affects hypophosphatasia over time in Russia | — | Moscow and 3 other locations | Recruiting | Feb 5, 2026 |
| Understanding Hypophosphatasia in Adults with Rheumatology Issues | — | Bonn, North Rhine-Westphali | Recruiting | Aug 27, 2024 |
| Registry of adults with hypophosphatasia | — | Bordeaux, France and 10 other locations | Recruiting | Oct 27, 2022 |
| Observational study of pediatric hypophosphatasia patients receiving treatment | — | Hartford, Connecticut and 11 other locations | Recruiting | Feb 10, 2022 |
| Observing the natural history of hypophosphatasia | — | Durham, North Carolina | Recruiting | Sep 11, 2014 |
| Registry for patients with rare diseases | — | Sioux Falls, South Dakota | Recruiting | Feb 15, 2013 |
All recruiting trials (6)
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How a single ALPL gene change affects hypophosphatasia over time in Russia
This observational study will follow children and adults with hypophosphatasia who carry one ALPL gene variant to see how their symptoms and health change during routine care in Russia.
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Understanding Hypophosphatasia in Adults with Rheumatology Issues
This study is trying to learn more about adults with hypophosphatasia who have joint and bone issues to help improve how they are diagnosed and treated.
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Registry of adults with hypophosphatasia
This study is tracking adults with hypophosphatasia to see how the condition affects their bone health and symptoms over time.
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Observational study of pediatric hypophosphatasia patients receiving treatment
This study is tracking kids with hypophosphatasia who are being treated with asfotase alfa to see how the treatment affects them over at least five years.
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Observing the natural history of hypophosphatasia
This study is tracking patients with hypophosphatasia to better understand how the condition affects them and how it runs in families.
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Registry for patients with rare diseases
This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.
Related topics
Quick answers
How many Hypophosphatasia clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (3 trials), Russia (1 trial), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.