Condition

Hepatocellular Carcinoma Non-resectable clinical trials and research

• 16Clinical trials
• 5Countries

Newest Hepatocellular Carcinoma Non-resectable clinical trials

All recruiting trials (16)

• Y-90 internal liver radiation followed by tremelimumab and durvalumab for liver cancer with portal vein thrombosis

  This will test whether Y-90 selective internal radiation (SIRT) followed by tremelimumab and durvalumab helps people with non-resectable hepatocellular carcinoma that involves the portal vein.

  Recruiting Phase 2 Center Eugene Marquis · Grenoble and 5 other locations · NCT07122089

• Combining Lenvatinib with SIRT for Advanced Liver Cancer

  This study is testing whether combining a cancer drug called lenvatinib with a type of radiation therapy can help people with advanced liver cancer that hasn't improved with other treatments.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06904196

• Combination treatment for large liver cancer with portal vein involvement

  This study is testing a new combination treatment for people with large liver cancer that has spread to the portal vein to see if it works better than the standard treatment.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06904183

• Yttrium-90 treatment for large liver cancer

  This study is testing whether a special radiation treatment using yttrium-90 can help people with large liver cancer that can’t be surgically removed feel better and live longer.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong and 1 other locations · NCT06707233

• Combination therapy for advanced liver cancer patients

  This study is testing a new combination treatment for patients with advanced liver cancer to see if it can improve their chances of survival and how well they tolerate it.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06607107

• Triple therapy for patients with unresectable liver cancer

  This study is testing a new combination treatment for patients with hard-to-treat liver cancer to see if it can help shrink tumors more and improve survival rates.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian and 3 other locations · NCT06561399

• Combining lenvatinib with TACE and HAIC for large liver cancer with portal vein thrombosis

  This study is testing a new combination treatment for people with large liver cancer and blood clots in the portal vein to see if it works better than just one of the treatments alone.

  Recruiting Phase 3 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06492395

• Combining DEB-TACE with HAIC for large liver cancer

  This study is testing if combining two types of chemotherapy treatments can help people with large liver cancer live longer and feel better compared to just one treatment.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06397235

• Combination treatment for advanced liver cancer

  This study is testing a new combination of treatments for advanced liver cancer to see if it helps patients live longer and feel better.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06397222

• Combination therapy for advanced liver cancer

  This study is testing a new combination of treatments for advanced liver cancer to see if it can shrink tumors enough to make them operable.

  Recruiting Phase 2 Tongji Hospital · Wuhan, Hubei · NCT06187961

• Combining Atezolizumab and Bevacizumab with Proton Radiotherapy for Liver Cancer

  This study is testing if combining two cancer-fighting drugs with a type of targeted radiation can help people with advanced liver cancer that can't be surgically removed feel better and live longer.

  Recruiting Phase 2 Chang Gung Memorial Hospital · Taoyuan City, Taiwan · NCT06133062

• Comparing two treatment combinations for advanced liver cancer

  This study is testing two different treatment combinations for advanced liver cancer to see which one helps patients live longer after their first round of a specific procedure.

  Recruiting Phase 3 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05985798

• Combining therapies for advanced liver cancer that can't be surgically removed

  This study is testing a new combination of treatments for patients with advanced liver cancer that can't be surgically removed to see if it helps them live longer and feel better than standard options.

  Recruiting at 2 sites Tongji Hospital · Quanzhou, Fujian and 1 other locations · NCT05713994

• Combining lenvatinib with iodine-125 seed brachytherapy for treating liver cancer

  This study is testing if combining a medication called lenvatinib with a special type of radiation therapy can help people with liver cancer that hasn't improved with other treatments live longer and feel better.

  Recruiting Phase 3 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05608213

• Targeted radiation (SBRT) after TACE for liver cancer

  This study tests whether adding stereotactic body radiation therapy (SBRT) after trans-arterial chemoembolization (TACE) helps people with early or intermediate hepatocellular carcinoma who cannot have surgery.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT04996914

• Evaluating biomarkers for predicting treatment response in liver cancer

  This study is testing if special imaging and blood tests can help predict how well people with inoperable liver cancer will respond to a new type of treatment.

  Recruiting Phase 2 Queen's Medical Center · Honolulu, Hawaii · NCT04965454

Related topics

Quick answers

How many Hepatocellular Carcinoma Non-resectable clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (12 trials), Germany (1 trial), Taiwan (1 trial), France (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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