Drug or treatment

Cadonilimab clinical trials

• 50Clinical trials
• 1New in 30 days
• 4Countries

Newest trials

All recruiting trials (50)

• Cadonilimab and Lenvatinib in advanced kidney cancer

  This study tests whether Cadonilimab plus Lenvatinib can help adults with unresectable, advanced renal cell carcinoma, especially clear cell type, after prior treatments.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Panjiayuan Nanli · NCT07909265

• FAPI-guided radiotherapy with cadonilimab plus chemo for colorectal cancer limited to the peritoneum

  Aims to see if adding targeted radiotherapy and cadonilimab immunotherapy to standard second-line chemotherapy helps adults with colorectal cancer that’s spread only to the peritoneum.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT07815834

• Cadonilimab with chemotherapy vs chemotherapy with/without nivolumab as first-line treatment for HER2-negative advanced gastric/GEJ cancer

  This study tests whether adding cadonilimab to chemotherapy helps people with newly diagnosed, unresectable or metastatic HER2-negative gastric/GEJ cancer live longer, compared with standard chemo alone (with or without nivolumab).

  Recruiting Phase 3 Akeso · Phoenix, Arizona and 24 other locations · NCT07700979

• Cadonilimab with chemotherapy for gastric or GEJ cancer

  This trial tests whether adding cadonilimab to standard chemotherapy is safe and effective for adults with locally advanced or resectable gastric or GEJ cancer.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07631000

• Cadonilimab plus high-dose interferon in neoadjuvant treatment for stage III/IV melanoma

  This trial tests whether giving cadonilimab with high-dose interferon before surgery can shrink tumors in people with stage III or resectable stage IV melanoma and whether it is safe.

  Recruiting Early Phase 1 Xijing Hospital · Xi'an · NCT07586904

• LM-302 plus oral S-1 and intraperitoneal paclitaxel, with or without cadonilimab, for Claudin 18.2–positive advanced stomach or GEJ cancer with peritoneal spread

  This trial tests whether adding cadonilimab to LM-302, oral S-1, and intraperitoneal paclitaxel helps people with Claudin 18.2–positive gastric or gastroesophageal junction cancer that has spread to the peritoneum.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Huangpu District · NCT07556640

• Long-term follow-up after cadonilimab (AK104) treatment

  This follow-up collects long-term health and survival information from people with advanced gastric cancer who previously received cadonilimab (AK104) in earlier clinical trials.

  Recruiting Akeso · Beijing · NCT07547787

• THIO and Cadonilimab for Resectable Liver Cancer

  This early-phase trial tests whether cadonilimab alone, ateganosine alone, or both together can safely help patients with resectable hepatocellular carcinoma.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07446257

• Cadonilimab with chemotherapy followed by concurrent chemoradiotherapy for locally advanced cervical cancer

  This phase 3 study will test whether adding cadonilimab to initial chemotherapy and then giving standard concurrent chemoradiotherapy helps women aged 18–70 with stage IIB–IVA locally advanced cervical cancer have better tumor responses and outcomes than standard chemoradiotherapy alone.

  Recruiting Phase 3 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07400536

• Perioperative cadonilimab plus neoadjuvant chemotherapy for resectable thoracic esophageal squamous cell carcinoma

  This trial will test whether adding cadonilimab to pre-surgery cisplatin/paclitaxel chemotherapy helps people with resectable esophageal squamous cell carcinoma have better outcomes.

  Recruiting Phase 2 Akeso · Xi'an · NCT07263919

• Cadonilimab plus cisplatin given before surgery for locally advanced cervical cancer

  This study will test whether giving cadonilimab together with cisplatin before surgery helps people with resectable, locally advanced cervical cancer.

  Recruiting Phase 2 The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07104149

• Cadonilimab with SOX chemotherapy given before and after surgery for removable stomach or gastroesophageal junction cancer

  This tests whether adding cadonilimab to SOX chemotherapy before and after surgery helps people with resectable stomach or gastroesophageal junction adenocarcinoma.

  Recruiting at 6 sites Phase 3 Akeso · Beijing, Beijing Municipality and 5 other locations · NCT07023315

• Cadonilimab plus an anti-angiogenic drug for metastatic dMMR/MSI-H colorectal cancer

  We will try cadonilimab together with an anti-angiogenic drug in people with metastatic dMMR/MSI‑H colorectal cancer, including those who are new to PD‑1/PD‑L1 therapy and those who have had it before.

  Recruiting Phase 2 Fudan University · Shanghai, China · NCT07003022

• Cadonilimab with chemoradiotherapy for oligometastatic Stage IVB cervical cancer

  This trial will test whether adding cadonilimab to chemoradiotherapy helps women with oligometastatic Stage IVB cervical cancer.

  Recruiting Phase 2 The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT06998394

• Neoadjuvant cadonilimab plus perioperative SOX for diffuse or mixed locally advanced stomach/GEJ cancer

  This will test whether adding cadonilimab to perioperative SOX chemotherapy helps people with diffuse or mixed locally advanced stomach or gastroesophageal junction adenocarcinoma.

  Recruiting at 4 sites Phase 3 Lanzhou University Second Hospital · Lanzhou, Gansu and 3 other locations · NCT06949033

• Using cadonilimab with bevacizumab and docetaxel for advanced non-small cell lung cancer

  This study is testing a new combination of treatments, including cadonilimab, bevacizumab, and docetaxel, to see if it can help people with advanced non-small cell lung cancer who haven't had success with other therapies.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06793813

• Combining Ligufalimab and Cadonilimab for Advanced Liver Cancers

  This study is testing if combining two treatments, Ligufalimab and Cadonilimab, can help people with advanced liver cancers that haven't improved with other therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06789848

• Combining Ivonescimab and Cadonilimab with chemotherapy for extensive stage small cell lung cancer

  This study is testing if combining two new drugs, Ivonescimab and Cadonilimab, with chemotherapy can help people with extensive stage small cell lung cancer feel better compared to standard treatments.

  Recruiting Phase 2 Sichuan University · Chengdu, Sichuan · NCT06769971

• Combining Cadonilimab with Stereotactic Radiotherapy for Brain Metastases Treatment

  This study is testing if combining a new drug called Cadonilimab with targeted radiation therapy can help people with brain metastases from lung cancer feel better and have fewer side effects than current treatments.

  Recruiting Phase 2 Xiangya Hospital of Central South University · Changsha, Hunan · NCT06702826

• IN10018 plus nab-paclitaxel and cadonilimab for metastatic or recurrent gastric-type cervical adenocarcinoma.

  This trial will test whether combining IN10018 with nab-paclitaxel and cadonilimab helps adult women whose gastric-type cervical adenocarcinoma has come back or spread after prior chemotherapy.

  Recruiting at 2 sites Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei and 1 other locations · NCT06654011

• Cadonilimab combination treatment for advanced HER2-positive gastric cancer

  This study is testing a new combination treatment with cadonilimab for people with advanced HER2-positive gastric cancer to see how well it works and how safe it is.

  Recruiting Phase 1/2 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT06650332

• Neoadjuvant triple therapy for liver cancer

  This study is testing a new combination treatment for liver cancer to see if it helps patients before they have surgery.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian and 5 other locations · NCT06569498

• Combining Cadonilimab with chemotherapy and bevacizumab for treating specific colorectal cancer

  This study is testing if adding Cadonilimab to chemotherapy and bevacizumab can help people with a specific type of colorectal cancer feel better and improve their treatment results.

  Recruiting Phase 3 Shengjing Hospital · Shenyang, Liaoning · NCT06566755

• Cadonilimab with S-1 or Capecitabine for advanced pancreatic cancer

  This study is testing if a new combination of Cadonilimab with either S-1 or capecitabine can help people with advanced pancreatic cancer who have already tried other treatments.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT06532617

• Combining cadonilimab with chemotherapy for resectable PD-L1 negative lung cancer

  This study is testing if combining a new drug called cadonilimab with chemotherapy can help people with resectable lung cancer that has low levels of PD-L1 feel better and improve their treatment outcomes.

  Recruiting Phase 2 Sichuan Cancer Hospital and Research Institute · Chengdu, Sichuan · NCT06532591

• Using cadonilimab with chemotherapy and radiation for advanced endometrial cancer

  This study is testing if adding cadonilimab to chemotherapy and radiation can help people with advanced endometrial cancer live longer and feel better.

  Recruiting Phase 2 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT06532539

• Treatment for advanced gastric cancer with peritoneal metastasis using a combination of therapies

  This study is testing a new combination of treatments for people with advanced gastric cancer that has spread to the abdomen to see if it can help slow down the disease and improve their health.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Huangpu District · NCT06519591

• Combining cadonilimab with chemotherapy for advanced lung cancer patients who failed immunotherapy

  This study is testing if adding a new drug called cadonilimab to chemotherapy can help adults with advanced lung cancer who haven't responded to other treatments.

  Recruiting Phase 2 China Three Gorges University, Yichang, China · Yichang · NCT06467500

• Combining cadonilimab with chemotherapy for advanced bile duct cancer

  This study is testing if combining a new drug called cadonilimab with chemotherapy can help people with advanced bile duct cancer who haven't responded to other treatments.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT06438822

• Treatment for advanced liver cancer using Cadonilimab and Lenvatinib

  This study is testing if a new combination of Cadonilimab, Lenvatinib, and chemotherapy can help people with advanced liver cancer that can't be surgically removed.

  Recruiting Phase 2 Hunan Cancer Hospital · Changsha, Hunan · NCT06406634

• Combination treatment for advanced pancreatic cancer

  This study is testing a new combination of treatments for people with advanced pancreatic cancer who haven't had treatment before to see if it helps manage their disease better.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06405490

• Combination of SBRT, chemotherapy, and AK104 for treating triple-negative breast cancer

  This study is testing a new treatment that combines radiation, chemotherapy, and an immune therapy to see if it helps people with triple-negative breast cancer respond better than standard treatments.

  Recruiting Phase 2 Hubei Cancer Hospital · Wuhan, Hubei · NCT06401005

• Combining AK104 and Lenvatinib with TACE for treating liver cancer

  This study is testing if combining two treatments, AK104 and lenvatinib, with a procedure called TACE can help people with liver cancer who can't have surgery feel better compared to just having TACE alone.

  Recruiting at 4 sites Phase 3 Akeso · Zhengzhou, Henan and 3 other locations · NCT06371157

• Combining Cadonilimab with chemotherapy for treating advanced triple-negative breast cancer

  This study is testing if combining a new antibody treatment called Cadonilimab with chemotherapy can help people with advanced triple-negative breast cancer feel better compared to standard treatments.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06367088

• Cadonilimab plus Adriamycin for advanced soft tissue sarcoma

  This study will try cadonilimab combined with adriamycin as first-line treatment for adults under 60 with advanced soft tissue sarcoma.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06367075

• Cadonilimab with paclitaxel micelles and cisplatin before surgery for locally advanced esophageal squamous cancer

  This trial will test whether giving cadonilimab together with paclitaxel polymeric micelles and cisplatin before surgery helps people with locally advanced esophageal squamous cell carcinoma.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06356688

• Combination treatment for advanced gastric cancer

  This study is testing a new combination of treatments for advanced stomach cancer to see if it works better than the standard treatment for patients who haven't responded to earlier therapies.

  Recruiting Phase 3 Akeso · Beijing · NCT06341335

• Combining cadonilimab and regorafenib for advanced liver cancer patients who didn't respond to previous treatment

  This study is testing if combining two drugs, cadonilimab and regorafenib, can help people with advanced liver cancer who didn't respond to earlier treatments.

  Recruiting Phase 2 Meng Chao Hepatobiliary Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06280105

• Combining Disitamab Vedotin and Cadonilimab for HER2-expressing Gastric Cancer

  This study is testing if combining two treatments, Disitamab Vedotin and Cadonilimab, can help people with advanced gastric cancer that has not responded to earlier treatments.

  Recruiting at 5 sites Phase 2/3 RemeGen Co., Ltd. · Beijing, Beijing Municipality and 11 other locations · NCT06221748

• Combination treatment for advanced colorectal cancer

  This study is testing a new combination treatment for people with advanced colorectal cancer to see if it helps them live longer without their cancer getting worse.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06218810

• Combination therapy of Cadonilimab and Lenvatinib for treating unresectable liver cancer

  This study is testing a combination of two drugs, Cadonilimab and Lenvatinib, to see if they can help people with liver cancer who can’t have surgery become eligible for surgery.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06215651

• Combination treatment for advanced gastric and gastroesophageal junction cancer

  This study is testing a new combination of two medications with chemotherapy to see if it can help adults with advanced stomach or gastroesophageal junction cancer.

  Recruiting Phase 2 Harbin Medical University · Harbin · NCT06196697

• Combination therapy for advanced liver cancer

  This study is testing a new combination of treatments for advanced liver cancer to see if it can shrink tumors enough to make them operable.

  Recruiting Phase 2 Tongji Hospital · Wuhan, Hubei · NCT06187961

• Combining Cadonilimab, Fruquintinib, and SBRT for Advanced Colorectal Cancer Treatment

  This study is testing a new combination of treatments for people with advanced colorectal cancer who haven't responded to previous therapies to see if it can help them feel better.

  Recruiting Phase 2 Huazhong University of Science and Technology · Wuhan, Hubei · NCT06168786

• Evaluating Cadonilimab for Cervical Cancer Treatment

  This study is testing a new drug called Cadonilimab to see if it can help people with persistent, recurrent, or metastatic cervical cancer feel better and live longer while also looking at its safety and costs.

  Recruiting Fujian Cancer Hospital · Fuzhou, Fujian · NCT06140589

• Combining cadonilimab with chemotherapy for gastric cancer treatment

  This study is testing if adding cadonilimab to chemotherapy can help people with stomach cancer before their surgery.

  Recruiting Phase 2 Akeso · Tianjin · NCT05960955

• Evaluating SPH4336 alone or with Cadonilimab for advanced solid tumors

  This study is testing whether a new drug called SPH4336, alone or with another drug called Cadonilimab, can help people with advanced solid tumors who can't have surgery or other local treatments.

  Recruiting at 16 sites Phase 1/2 Shanghai Pharmaceuticals Holding Co., Ltd · Fuzhou, Fujian and 15 other locations · NCT05944224

• Combination treatment for recurrent cervical cancer

  This study is testing a new combination of treatments for people with recurrent cervical cancer to see if it helps them feel better and live longer.

  Recruiting Phase 2 Zhongnan Hospital · Wuhan, Hubei · NCT05817214

• Combining Cadonilimab with Radiotherapy for Advanced Cervical Cancer

  This study is testing if a new treatment combining Cadonilimab with radiation therapy can help women with advanced cervical cancer who can't handle chemotherapy.

  Recruiting Phase 2 Chongqing University Cancer Hospital · Chongqing, CHN · NCT05687851

• Neoadjuvant treatment for locally advanced colorectal cancer using mFOLFOXIRI and Cadonilimab

  This study is testing a new combination of chemotherapy and an immune treatment to see if it helps people with locally advanced colorectal cancer do better before surgery.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT05571644

Quick answers

How many clinical trials of Cadonilimab are recruiting right now?

50, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (47 trials), United States (4 trials), Germany (1 trial), Poland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 34, Phase 3: 8, Phase 1/2: 2, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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