Condition

CLL (Chronic Lymphocytic Leukemia) clinical trials and research

• 6Clinical trials
• 3Countries

Newest CLL (Chronic Lymphocytic Leukemia) clinical trials

All recruiting trials (6)

• MRD-guided Zanubrutinib + Sonrotoclax in new high-risk CLL/SLL

  This trial tests a time-limited, MRD-guided combination therapy with zanubrutinib and sonrotoclax for adults up to 75 with previously untreated high-risk CLL/SLL.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07671378

• Whole-food, plant-based diet for people with early-stage CLL

  See if a 4-week whole-food, plant-based diet changes immune activity and blood counts in people with early-stage, untreated CLL.

  Recruiting Technical University of Munich · München, Bavaria · NCT07487428

• Rocbrutinib versus pirtobrutinib for adults with relapsed or refractory CLL/SLL after a covalent BTK inhibitor

  This compares rocbrutinib and pirtobrutinib to see which works better and is safer for adults whose CLL or SLL returned or didn't respond after a covalent BTK inhibitor.

  Recruiting at 6 sites Phase 3 Newave Pharmaceutical Inc · Skokie, Illinois and 6 other locations · NCT07342478

• Post-transplant cyclophosphamide strategies to prevent graft-versus-host disease after mismatched unrelated donor stem cell transplant

  This platform tests whether adding different drug combinations with post-transplant cyclophosphamide prevents graft‑versus‑host disease better than the standard regimen for adults getting mismatched unrelated donor peripheral blood stem cell transplants for blood cancers.

  Recruiting at 13 sites Phase 2 Center for International Blood and Marrow Transplant Research · Birmingham, Alabama and 12 other locations · NCT06859424

• ZE50-0134 for relapsed or refractory CLL, SLL, and select low-grade lymphomas

  This study tests whether a new drug called ZE50-0134 is safe and has anti-lymphoma activity in adults with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, or certain low-grade lymphomas.

  Recruiting at 4 sites Phase 1 Lomond Therapeutics Holdings, Inc. · Louisville, Kentucky and 4 other locations · NCT06708897

• Observing the natural history of certain blood cancers

  This study is tracking how certain blood cancers develop over time in patients to learn more about them and find new treatment options.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00923507

Related topics

Quick answers

How many CLL (Chronic Lymphocytic Leukemia) clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (4 trials), Germany (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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