Condition

Marginal Zone Lymphoma(MZL) clinical trials and research

• 8Clinical trials
• 3Countries

Newest Marginal Zone Lymphoma(MZL) clinical trials

All recruiting trials (8)

• Orelabrutinib plus rituximab with optional lenalidomide for untreated marginal zone lymphoma using a response-adapted plan

  This will test whether giving orelabrutinib with rituximab, and adding lenalidomide for those who don't fully respond, helps people with newly diagnosed marginal zone lymphoma achieve complete remissions.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07448324

• Orelabrutinib alone or with a CD20 antibody for people newly diagnosed with marginal zone lymphoma

  This trial tests if orelabrutinib by itself or together with a CD20 antibody can treat adults who have just been diagnosed with marginal zone lymphoma.

  Recruiting Phase 4 Beijing Tongren Hospital · Beijing and 2 other locations · NCT07355699

• Orelabrutinib plus zebetuzumab and lenalidomide vs bendamustine‑rituximab for newly diagnosed marginal zone lymphoma

  This study will test whether a combination of orelabrutinib, zebetuzumab, and lenalidomide helps people with newly diagnosed marginal zone lymphoma compared with a standard bendamustine plus rituximab regimen.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07208981

• First-line treatment with orelabrutinib plus rituximab for marginal zone lymphoma

  This will test whether taking orelabrutinib together with rituximab works and is safe as a first systemic treatment for adults with marginal zone lymphoma.

  Recruiting at 18 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 17 other locations · NCT07022223

• Assessing the effectiveness and safety of zanubrutinib for marginal zone lymphoma patients in Italy

  This study is trying to see how well and safely zanubrutinib works for people in Italy with relapsed or hard-to-treat marginal zone lymphoma who have already received treatment.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Alessandria, Alessandria and 14 other locations · NCT06823960

• MZL-IPI–guided targeted therapy for untreated marginal zone lymphoma

  This trial will try different targeted drug combinations based on MZL-IPI risk to treat adults newly diagnosed with marginal zone lymphoma who need systemic therapy.

  Recruiting at 3 sites Phase 2 Ruijin Hospital · Shanghai, China and 2 other locations · NCT06793189

• ZE50-0134 for relapsed or refractory CLL, SLL, and select low-grade lymphomas

  This study tests whether a new drug called ZE50-0134 is safe and has anti-lymphoma activity in adults with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, or certain low-grade lymphomas.

  Recruiting at 4 sites Phase 1 Lomond Therapeutics Holdings, Inc. · Louisville, Kentucky and 4 other locations · NCT06708897

• Orelabrutinib plus rituximab versus R‑CVP as first-line treatment for marginal zone lymphoma

  This test will see if orelabrutinib plus rituximab, followed by orelabrutinib maintenance, works as well or better than standard R‑CVP chemotherapy for adults with untreated marginal zone lymphoma.

  Recruiting Phase 2 The First Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT06700798

Related topics

Quick answers

How many Marginal Zone Lymphoma(MZL) clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in China (6 trials), United States (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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