ZE50-0134 for relapsed or refractory CLL, SLL, and select low-grade lymphomas

Phase 1 Study of ZE50-0134 in Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), and Select Low-grade Lymphomas

This study tests whether a new drug called ZE50-0134 is safe and has anti-lymphoma activity in adults with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, or certain low-grade lymphomas.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 66 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Lomond Therapeutics Holdings, Inc. (industry)
• Drugs / interventions: prednisone
• Locations: 4 sites (Louisville, Kentucky and 3 other locations)
• Trial ID: NCT06708897 on ClinicalTrials.gov

What this trial studies

This Phase 1, open-label, multicenter trial uses a 3+3 dose-escalation design followed by dose-expansion cohorts to study ZE50-0134. Part 1 enrolls sequential cohorts to establish the maximum tolerated dose and gather safety, pharmacokinetic, and pharmacodynamic data. Part 2 expands at the biologically effective dose or MTD (and one dose lower) and includes venetoclax‑naïve CLL/SLL patients to further characterize tolerability and preliminary antitumor activity. The study is conducted at multiple US centers and collects early efficacy signals alongside detailed safety and PK/PD results.

Who should consider this trial

Good fit: Adults (≥18) with symptomatic relapsed or refractory CLL/SLL or select low-grade lymphomas who meet the protocol's prior-therapy requirements (e.g., prior BTKi and venetoclax exposure for part 1, or prior BTKi and venetoclax‑naïve for part 2, with other eligibility criteria met) are the intended participants.

Not a fit: Patients who are treatment‑naïve, who cannot tolerate trial procedures, or who do not meet the specified prior-therapy or organ-function criteria are unlikely to qualify or derive benefit from this study.

Why it matters

Potential benefit: If successful, ZE50-0134 could provide a new therapy option with manageable safety and anti-lymphoma activity for patients whose disease has returned or not responded to prior treatments.

How similar studies have performed: Targeted agents such as BTK inhibitors and venetoclax have shown substantial activity in CLL/SLL, but ZE50-0134 is a novel agent and its safety and efficacy in humans remain unproven.

Eligibility criteria

Inclusion Criteria:

1. Men and women aged ≥18 years.
2. Disease as defined below:

   Part 1: Patients with symptomatic CLL or SLL (defined by iwCLL) without del(17p)/TP53 must have received ≥2 prior therapies that have included a BTKi and venetoclax (or declined this) or Patients with progressive low-grade lymphoma that includes marginal zone lymphoma, lymphoplasmacytic lymphoma (including Waldenstrom's macroglobulinemia) who have received at least 2 therapies including a BTKi and CD20 antibody-based therapy.

   Part 2: Patients with symptomatic CLL or SLL (defined by iwCLL) must have received ≥1 prior therapies that have included a BTKi and be venetoclax naive.
3. Prior to beginning part 2, an activation amendment will be submitted to the FDA that includes safety, pharmacokinetics, pharmacodynamics and early efficacy data from the Part 1 portion. At this time, we may also include cohorts of specific types of low-grade lymphoma as well. Adequate bone marrow, liver, and renal functions as assessed by the following laboratory requirements to be conducted within 7 days before the first dose of study drug:

   * Absolute neutrophil count (ANC) \> 0.75 x 109/L. For subjects with documented bone marrow involvement ≥ 0.5 x 109/L
   * Platelet count \> 50 x 109/L. For subjects with documented bone marrow involvement ≥ 30 x 109/L
   * Serum aspartate transaminase (AST/SGOT) or alanine transaminase (ALT/SGPT) ≤ 3.0 x upper limit of normal (ULN)
   * Total bilirubin ≤ 1.5 x ULN
   * Creatinine or Cystatin C glomerular filtration rate (GFR) ≥60 mL/min. Estimated GFR (eGFR) according to the Modification of Diet in Renal Disease Study Group (MDRD) formula and expressed in mL/min. To convert mL/min/1.73 m2 to mL/min multiply by the individual's BSA calculated using an appropriate formula and divide by 1.73 Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less Negative serum or urine pregnancy test must be obtained within 7 days before the first dose of study drug in women of childbearing potential. Negative results must also be available before each cycle.

Postmenopausal women, as defined below, are exempt from pregnancy testing:

* Age \>50 years with amenorrhea for at least 12 months or
* Age ≤50 years with 6 months of spontaneous amenorrhea and follicle stimulating hormone (FSH) level within postmenopausal range (\>40 mIU/mL) OR
* Permanently sterilized women (e.g., hysterectomy, bilateral salpingectomy, or uterine ablation) Women and men of reproductive potential must agree to use highly effective contraception when sexually active. This applies for the period between signing of the informed consent and 90 days after the last administration of study drug. These methods should be documented in source documents. The investigator or a designated associate is requested to advise the subject on how to achieve highly effective birth control. Ability to understand and the willingness to sign a written informed consent. A signed informed consent (including consent for genetic biomarker

Exclusion Criteria:

Subjects will be excluded from the study if they display any of the following criteria:

1. FOR PART 2 ONLY

   \- No prior venetoclax treatment

   FOR BOTH PARTS ALL THE FOLLOWING APPLY:
2. Know active Richter's transformation. Patients who have been treated for this diagnosis and have been in remission for \> 2 years without evidence of this and who have only CLL are considered eligible
3. Known hypersensitivity to the study drug or excipients of the preparation or any agent given in association with this study.
4. Clinically significant cardiac disease including congestive heart failure \> New York Heart Association (NYHA) Class II, evidence for uncontrolled coronary artery disease (e.g., unstable angina (anginal symptoms at rest) or new-onset angina (within the last 6 months or myocardial infarction within the past 6 months before first dose, major regional wall motion abnormalities upon baseline echocardiography), and cardiac arrhythmias requiring anti- arrhythmic therapy except for beta-blockers and digoxin.
5. Known Active cytomegalovirus (CMV), hepatitis B or C virus infection.
6. Known Active SARS-CoV-2 infection; prior SARS-CoV-2 infection allowed if completely recovered \> 14 days.
7. Active clinically serious infections of Grade \>2, requiring parenteral therapy; Subjects may be eligible after infection resolves.
8. Uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenic purpura within 28 days of enrolment.
9. Allogeneic bone marrow transplant within 4 months before first dose of study drug (Subjects must have completed immunosuppressive therapy before enrollment).
10. Active cancer that limits expected survival to \< 2 years or requires active therapy concomitant with this treatment. Exclusions would be localized skin cancer, breast cancer, prostate cancer that are resected or malignancies treated with hormonal or immune therapies alone. All cases of secondary cancer should be discussed with the medical monitor.
11. A physical exam or laboratory finding that contraindicates the use of investigational therapy or otherwise places the subject at excessively high risk for treatment, as determined by the investigator. A discussion between the investigator and sponsor regarding eligibility is encouraged for such cases.
12. Unresolved toxicity of previous treatments (excluding cases of alopecia) Grade ≥2.
13. Requires ongoing immunosuppressive therapy, including systemic (e.g., intravenous or oral) corticosteroids for the treatment of cancer or other conditions. Note: Subjects may use topical or inhaled corticosteroids or low-dose steroids (≤10 mg of prednisone or equivalent per day) as therapy for comorbid conditions. Short courses of steroids before first dose are allowed for tumor flare.
14. Major surgery or significant trauma within 4 weeks before the first dose of study drug.
15. Breastfeeding women: breastfeeding women have to discontinue breastfeeding before onset of and during treatment and should be discontinued for at least 3 months after end of treatment.
16. Subjects with QTcF \> 470 msec that cannot be corrected with electrolyte replacement, hydration, or medication modifications.

Where this trial is running

Louisville, Kentucky and 3 other locations

• Norton Cancer Institute, St. Matthews Campus — Louisville, Kentucky, United States (RECRUITING)
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (RECRUITING)
• University of Cincinnati — Cincinnati, Ohio, United States (RECRUITING)
• The Ohio State University — Columbus, Ohio, United States (RECRUITING)

Study contacts

• Study coordinator: Ekaterina Dokukina, PhD MD

Conditions: CLL / SLL, CLL, SLL