Condition
Alpha-1 Antitrypsin Deficiency (AATD) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Alpha-1 Antitrypsin Deficiency (AATD) clinical trials that are recruiting, at sites in 5 countries (most in United Kingdom (2), Turkey (Türkiye) (1), Australia (1)). 1 was first registered in the last 30 days. By phase: Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1New in 30 days
- 5Countries
Newest Alpha-1 Antitrypsin Deficiency (AATD) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Chronic Respiratory Disease Participant Engagement | — | London | Recruiting | Nov 9, 2026 |
| Treatment with TSRA-196 for adults with PiZZ Alpha-1 Antitrypsin Deficiency | Phase 1/2 | Jacksonville, Florida and 8 other locations | Recruiting | Nov 12, 2025 |
| Testing for alpha-1 antitrypsin deficiency in people with airway obstruction | — | Muğla, Menteşe | Recruiting | Sep 3, 2025 |
All recruiting trials (3)
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Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
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Treatment with TSRA-196 for adults with PiZZ Alpha-1 Antitrypsin Deficiency
This study tests TSRA-196 in adults with PiZZ AATD to see if the treatment is safe and tolerable and to explore its effects on lung and liver disease.
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Testing for alpha-1 antitrypsin deficiency in people with airway obstruction
This project will test whether people with shortness of breath and airway obstruction on spirometry have a higher rate of alpha-1 antitrypsin deficiency by measuring blood AAT levels and common gene mutations.
Related topics
Quick answers
How many Alpha-1 Antitrypsin Deficiency (AATD) clinical trials are recruiting right now?
3, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 5 countries. The most sites are in United Kingdom (2 trials), Turkey (Türkiye) (1 trial), Australia (1 trial), Sweden (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.