Testing for alpha-1 antitrypsin deficiency in people with airway obstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective cross-sectional screening of patients presenting to a pulmonary outpatient clinic with dyspnea who undergo routine spirometry. Consecutive eligible patients will give a small blood sample for serum AAT level measurement and genotyping for common AATD mutations, and results will be compared across the screened population. The study excludes patients with known COPD, asthma, bronchiectasis, certain inflammatory, liver, haematological or renal diseases, pregnant women, and oral contraceptive users. The goal is to find previously undiagnosed AATD cases so they can receive appropriate management and family testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Achieve a post-bronchodilator FEV1/FVC ratio of 70 or above in the respiratory function test.
* Be able to speak and understand Turkish.
* Have the mental and cognitive capacity to understand the questions asked.

Exclusion Criteria:

* Renal dysfunction; acute inflammation; rheumatological, haematological, or liver diseases; COPD; asthma; bronchiectasis; and a history of malignancy.
* Pregnant women and users of oral contraceptives.

Where it's running

• Muğla Training and Research Hospital
  Muğla, Menteşe, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ozlem Sengoren Dikis, Associate Professor
• Email: ozlemsengoren@mu.edu.tr
• Phone: +905073849700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.