Young Onset Parkinson's Disease: Subtypes and Mechanisms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares clinical features and biological data from blood, skin biopsies, and, for some participants, lumbar puncture samples among young-onset Parkinson's disease patients, late-onset patients, and healthy controls. Participants provide demographic and clinical information through questionnaires and exams, and give biological samples to identify potential biomarkers and pathogenic pathways. The study includes a single in-person visit per participant at NYU Langone Health, with additional lumbar puncture data for a subset. Findings may inform disease mechanisms and aid in stratifying patients for future therapeutic trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

YOPD cohort:

1. Male or female 18 years or older (inclusive) of any race and ethnicity
2. Diagnosis of Parkinson's disease (PD) confirmed by a movement disorder specialist and with an age of onset of less than or equal to the age of 50 years old
3. Willingness to undergo a skin punch biopsy

LOPD cohort:

1. Male or female 18 years or older (inclusive) of any race and ethnicity
2. Diagnosis of PD confirmed by a movement disorder specialist and with an age of onset after the age of 50 years

Healthy Control cohort:

1. Male or female 18 years or older (inclusive) of any race and ethnicity
2. Never been diagnosed with PD as reported by medical history and as assessed by study PI

Exclusion Criteria:

1. Diagnosis of atypical parkinsonism (i.e. progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy) or secondary parkinsonism (i.e. normal pressure hydrocephalus, drug-induced parkinsonism).
2. Clinical history of autoimmune or chronic inflammatory disorder or exposure to chronic immunosuppressant or immunomodulatory medications.
3. Pregnancy
4. Dermatological conditions that would prevent performing skin punch biopsies

Where it's running

• NYU Langone Health
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Giulietta Riboldi, MD, PhD — NYU Langone Health
• Study coordinator: Mark Belio
• Email: Mark.Belio@nyulangone.org
• Phone: 646-501-4367

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.